WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H317982
CAS#: 22195-34-2
Description: Guanadrel Sulfate is a postganglionic adrenergic blocking agent. The uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.
Hodoodo Cat#: H317982
Name: Guanadrel Sulfate
CAS#: 22195-34-2
Chemical Formula: C10H21N3O6S
Exact Mass: 311.12
Molecular Weight: 311.360
Elemental Analysis: C, 38.58; H, 6.80; N, 13.50; O, 30.83; S, 10.30
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Synonym: Guanadrel Sulfate; Hylorel; Hyloride; CL 1388R; U 28288D; CHEBI:5556; Hylorel;
IUPAC/Chemical Name: 2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine;sulfuric acid
InChi Key: RTEVGQJRTFFMLL-UHFFFAOYSA-N
InChi Code: InChI=1S/2C10H19N3O2.H2O4S/c2*11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h2*8H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)
SMILES Code: C1CCC2(CC1)OCC(O2)CN=C(N)N.C1CCC2(CC1)OCC(O2)CN=C(N)N.OS(=O)(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 311.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Darga LL, Hakim MJ, Lucas CP, Franklin BA. Comparison of the effects of
guanadrel sulfate and propranolol on blood pressure, functional capacity, serum
lipoproteins and glucose in systemic hypertension. Am J Cardiol. 1991 Mar
15;67(7):590-6. PubMed PMID: 2000792.
2: Sekkarie MA, Egan BM, Neubig RR, Supiano MA. Sensitization of human alpha 1-
and alpha 2-adrenergic venous responses by guanadrel sulfate. Clin Pharmacol
Ther. 1990 Nov;48(5):537-43. PubMed PMID: 2171846.
3: Palmer JD, Nugent CA. Guanadrel sulfate: a postganglionic sympathetic
inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy.
1983 Jul-Aug;3(4):220-9. PubMed PMID: 6351026.
4: Nugent CA, Palmer JD, Ursprung JJ. Guanadrel sulfate compared with methyldopa
for mild and moderate hypertension. Pharmacotherapy. 1982 Nov-Dec;2(6):378-83.
PubMed PMID: 6762533.
5: Cangiano JL, Bloomfield DK. Hemodynamic effects of a new antihypertensive
agent, guanadrel sulfate. Curr Ther Res Clin Exp. 1969 Dec;11(12):736-44. PubMed
PMID: 4984037.
6: Bloomfield DK, Cangiano JL. Clinical experience with a new antihypertensive
agent, guanadrel sulfate. Curr Ther Res Clin Exp. 1969 Dec;11(12):727-35. PubMed
PMID: 4984036.