WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558277
CAS#: 5428-80-8
Description: Vacquinol-1, also known as NSC 13316, is an activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells. Vacquinol-1 has beneficial effects on a glioblastoma multiforme mouse model by oral administration. In glioblastoma cells, Vacquinol-1 targets macropinocytosis, a cellular process that will not lead to cell death in normal cells.
Hodoodo Cat#: H558277
Name: Vacquinol-1
CAS#: 5428-80-8
Chemical Formula: C21H21ClN2O
Exact Mass: 352.13
Molecular Weight: 352.862
Elemental Analysis: C, 71.48; H, 6.00; Cl, 10.05; N, 7.94; O, 4.53
Synonym: NSC 13316; NSC-13316; NSC13316; Vacquinol-1
IUPAC/Chemical Name: (2-(4-chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol
InChi Key: VKLJPGAHSLIQKH-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21ClN2O/c22-15-10-8-14(9-11-15)20-13-17(16-5-1-2-6-18(16)24-20)21(25)19-7-3-4-12-23-19/h1-2,5-6,8-11,13,19,21,23,25H,3-4,7,12H2
SMILES Code: ClC1=CC=C(C2=NC(C=CC=C3)=C3C(C(O)C4NCCCC4)=C2)C=C1
Appearance: White to beige solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 352.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Aki T, Funakoshi T, Uemura K. Regulated necrosis and its implications in toxicology. Toxicology. 2015 Jul 3;333:118-26. doi: 10.1016/j.tox.2015.04.003. Epub 2015 Apr 9. Review. PubMed PMID: 25865964.
2: Shi Y, Lim SK, Parada LF. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1. doi: 10.1038/cr.2014.72. Epub 2014 May 30. PubMed PMID: 24874955; PubMed Central PMCID: PMC4123293.
3: Gilbertson RJ. Driving glioblastoma to drink. Cell. 2014 Apr 10;157(2):289-90. doi: 10.1016/j.cell.2014.03.034. PubMed PMID: 24725398.
4: Kitambi SS, Toledo EM, Usoskin D, Wee S, Harisankar A, Svensson R, Sigmundsson K, Kalderén C, Niklasson M, Kundu S, Aranda S, Westermark B, Uhrbom L, Andäng M, Damberg P, Nelander S, Arenas E, Artursson P, Walfridsson J, Forsberg Nilsson K, Hammarström LG, Ernfors P. Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule. Cell. 2014 Apr 10;157(2):313-28. doi: 10.1016/j.cell.2014.02.021. Epub 2014 Mar 20. PubMed PMID: 24656405.
