WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H522661
CAS#: 1082058-99-8
Description: TUG-424 is a a potent and selective free fatty acid receptor 1 agonist. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.
Hodoodo Cat#: H522661
Name: TUG-424
CAS#: 1082058-99-8
Chemical Formula: C18H16O2
Exact Mass: 264.12
Molecular Weight: 264.324
Elemental Analysis: C, 81.79; H, 6.10; O, 12.11
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Synonym: TUG-424; TUG424; TUG 424.
IUPAC/Chemical Name: 3-(4-(o-tolylethynyl)phenyl)propanoic acid
InChi Key:
InChi Code:
SMILES Code: O=C(O)CCC1=CC=C(C#CC2=CC=CC=C2C)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 264.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hagesaether E, Christiansen E, Due-Hansen ME, Ulven T. Mucus can change the
permeation rank order of drug candidates. Int J Pharm. 2013 Aug
16;452(1-2):276-82. doi: 10.1016/j.ijpharm.2013.05.036. Epub 2013 May 23. PubMed
PMID: 23707884.
2: Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV,
Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA,
Kostenis E, Kassack MU, Ulven T. Discovery of a potent and selective free fatty
acid receptor 1 agonist with low lipophilicity and high oral bioavailability. J
Med Chem. 2013 Feb 14;56(3):982-92. doi: 10.1021/jm301470a. Epub 2013 Jan 22.
PubMed PMID: 23294321.
3: Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A,
Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T.
Discovery of potent and selective agonists for the free fatty acid receptor 1
(FFA(1)/GPR40), a potential target for the treatment of type II diabetes. J Med
Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178. PubMed PMID: 18947221.