WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H319938
CAS#: 43200-80-2
Description: NOTE: Zopiclone has been discontinued | Zopiclone is a nonbenzodiazepine hypnotic agent used in the treatment of insomnia. It is a cyclopyrrolone, which increases the normal transmission of the neurotransmitter GABA in the central nervous system, as benzodiazepines do, but in a different way. As zopiclone is sedating, it is marketed as a sleeping pill. It works by causing a depression or tranquilization of the central nervous system.
Hodoodo Cat#: H319938
Name: Zopiclone
CAS#: 43200-80-2
Chemical Formula: C17H17ClN6O3
Exact Mass: 388.11
Molecular Weight: 388.812
Elemental Analysis: C, 52.52; H, 4.41; Cl, 9.12; N, 21.62; O, 12.34
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: RP-27267; RP27267; RP 27267; BRN 0768704; Zopiclone. brand names Zimovane and Imovane.
IUPAC/Chemical Name: 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate
InChi Key: GBBSUAFBMRNDJC-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3
SMILES Code: O=C(N1CCN(C)CC1)OC2N(C3=NC=C(Cl)C=C3)C(C4=NC=CN=C42)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 388.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Curreen M, Lidmila J. Zopiclone: Is there cause for concern in addiction services and general practice? Int J Risk Saf Med. 2014;26(4):183-9. doi: 10.3233/JRS-140633. Review. PubMed PMID: 25420760.
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16: Lader M. Zopiclone: is there any dependence and abuse potential? J Neurol. 1997 Apr;244(4 Suppl 1):S18-22. Review. PubMed PMID: 9112585.
17: Hajak G, Rodenbeck A. Clinical management of patients with insomnia. The role of zopiclone. Pharmacoeconomics. 1996;10 Suppl 1:29-38. Review. PubMed PMID: 10163425.
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