WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H523113
CAS#: 1600515-49-8
Description: Tilfrinib is a potent and selective breast tumor kinase (Brk) inhibitor (IC50 = 3.15 nM). Tilfrinib has >1000-fold selectivity for Brk over a panel of other kinases and inhibits proliferation of breast cancer cells in vitro.
Hodoodo Cat#: H523113
Name: Tilfrinib
CAS#: 1600515-49-8
Chemical Formula: C17H13N3O
Exact Mass: 275.11
Molecular Weight: 275.310
Elemental Analysis: C, 74.17; H, 4.76; N, 15.26; O, 5.81
Synonym: Tilfrinib;
IUPAC/Chemical Name: 3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol
InChi Key: RXPZOSHFGJWSLQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13N3O/c21-12-5-3-4-11(10-12)19-15-8-9-18-17-16(15)13-6-1-2-7-14(13)20-17/h1-10,21H,(H2,18,19,20)
SMILES Code: OC1=CC=CC(NC2=C3C(NC4=C3C=CC=C4)=NC=C2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 275.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |