WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H318885
CAS#: 64-77-7
Description: Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.
Hodoodo Cat#: H318885
Name: Tolbutamide
CAS#: 64-77-7
Chemical Formula: C12H18N2O3S
Exact Mass: 270.10
Molecular Weight: 270.348
Elemental Analysis: C, 53.31; H, 6.71; N, 10.36; O, 17.75; S, 11.86
Synonym: Tolbutamide, Artosin, Diabetol, Orinase
IUPAC/Chemical Name: 1-butyl-3-(4-methylphenyl)sulfonylurea
InChi Key: JLRGJRBPOGGCBT-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
SMILES Code: O=C(NS(=O)(C1=CC=C(C)C=C1)=O)NCCCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 270.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
1: Emoto M, Nishizawa Y. [Acute insulin response to tolbutamide of pancreatic beta-cell]. Nihon Rinsho. 2002 Aug;60 Suppl 8:319-24. Review. Japanese. PubMed PMID: 12355766.
2: Hosaka T, Oka Y. [Tolbutamide, glucagon, leucine and arginine tolerance test]. Nihon Rinsho. 1997 Apr;55 Suppl 2:423-7. Review. Japanese. PubMed PMID: 9172561.
3: Fuà C, Mazzi F, Peracino. [Intravenous tolbutamide test in the diagnosis of diabetes. Critical review and case studies]. Clin Ter. 1972 Feb 15;60(3):229-43. Review. Italian. PubMed PMID: 4579709.
4: Back DJ, Orme ML. Genetic factors influencing the metabolism of tolbutamide. Pharmacol Ther. 1989;44(2):147-55. Review. PubMed PMID: 2519343.
5: Frawley TF, Pensuwan S. Hypoglycemia: tolbutamide and leucine tests in insulinoma. Med Clin North Am. 1968 Mar;52(2):283-94. Review. PubMed PMID: 4297807.
6: Rambert P, Thervet F. [The intravenous tolbutamide test]. Journ Annu Diabetol Hotel Dieu. 1968;9:331-45. Review. French. PubMed PMID: 4918340.
