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Triamterene
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H318902

CAS#: 396-01-0

Description: Triamterene is a potassium-sparing diuretic used in combination with thiazide diuretics for the treatment of hypertension and edema. Triamterene directly blocks the epithelial sodium channel (ENaC) on the lumen side of the kidney collecting tubule. Other diuretics cause a decrease in the sodium concentration of the forming urine due to the entry of sodium into the cell via the ENaC, and the concomitant exit of potassium from the principal cell into the forming urine. Blocking ENaC prevents this from happening. Amiloride works in the same way. Sodium channel blockers directly inhibit the entry of sodium into the sodium channels.

Chemical Structure

Triamterene

CAS# 396-01-0

Instruction

Theoretical Analysis

Hodoodo Cat#: H318902
Name: Triamterene
CAS#: 396-01-0
Chemical Formula: C12H11N7
Exact Mass: 253.11
Molecular Weight: 253.269
Elemental Analysis: C, 56.91; H, 4.38; N, 38.71

Price and Availability

Size	Price	Availability
5g	USD 250	2 Weeks
25g	USD 600	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: BRN 0266723; BRN0266723; BRN-0266723; Triamterene; Diucelpin; Diurene

IUPAC/Chemical Name: 6-phenylpteridine-2,4,7-triamine

InChi Key: FNYLWPVRPXGIIP-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)

SMILES Code: NC1=NC(N)=C2N=C(C3=CC=CC=C3)C(N)=NC2=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 253.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Crowson MG, Patki A, Tucci DL. A Systematic Review of Diuretics in the Medical Management of Ménière's Disease. Otolaryngol Head Neck Surg. 2016 Mar 1. pii: 0194599816630733. [Epub ahead of print] Review. PubMed PMID: 26932948.

2: Treating essential hypertension. The first choice is usually a thiazide diuretic. Prescrire Int. 2014 Sep;23(152):215-20. Review. PubMed PMID: 25325125.

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4: Heran BS, Chen JM, Wang JJ, Wright JM. Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension. Cochrane Database Syst Rev. 2012 Nov 14;11:CD008167. doi: 10.1002/14651858.CD008167.pub3. Review. PubMed PMID: 23152254.

5: Melcescu E, Phillips J, Moll G, Subauste JS, Koch CA. 11Beta-hydroxylase deficiency and other syndromes of mineralocorticoid excess as a rare cause of endocrine hypertension. Horm Metab Res. 2012 Nov;44(12):867-78. doi: 10.1055/s-0032-1321851. Epub 2012 Aug 29. Review. PubMed PMID: 22932914.

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7: Hueskes BA, Roovers EA, Mantel-Teeuwisse AK, Janssens HJ, van de Lisdonk EH, Janssen M. Use of diuretics and the risk of gouty arthritis: a systematic review. Semin Arthritis Rheum. 2012 Jun;41(6):879-89. doi: 10.1016/j.semarthrit.2011.11.008. Epub 2012 Jan 4. Review. PubMed PMID: 22221907.

8: Kohjimoto Y, Sasaki Y, Hara I. [Clinical strategies for prevention of drug-induced urinary calculi]. Clin Calcium. 2011 Oct;21(10):1457-63. doi: CliCa111014571463. Review. Japanese. PubMed PMID: 21960230.

9: Epstein M, Calhoun DA. Aldosterone blockers (mineralocorticoid receptor antagonism) and potassium-sparing diuretics. J Clin Hypertens (Greenwich). 2011 Sep;13(9):644-8. doi: 10.1111/j.1751-7176.2011.00511.x. Epub 2011 Aug 9. Review. PubMed PMID: 21896143.

10: Vicart S, Sternberg D, Arzel-Hézode M, Franques J, Bendahhou S, Lory P, Hainque B, Fournier E, Nicole S, Fontaine B. Hypokalemic Periodic Paralysis. 2002 Apr 30 [updated 2014 Jul 31]. In: Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from http://www.ncbi.nlm.nih.gov/books/NBK1338/ PubMed PMID: 20301512.

11: Heran BS, Chen JM, Wang JJ, Wright JM. Blood pressure lowering efficacy of potassium-sparing diuretics (that block the epithelial sodium channel) for primary hypertension. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD008167. doi: 10.1002/14651858.CD008167.pub2. Review. Update in: Cochrane Database Syst Rev. 2012;11:CD008167. PubMed PMID: 20091662.

12: Pechlivanis I, Scholz M, Harders A, Schmieder K. [Asynchronous lumbar synovial cysts after surgical resection: a case report]. Z Orthop Unfall. 2009 Mar-Apr;147(2):236-8. doi: 10.1055/s-2008-1038980. Epub 2009 Apr 8. Review. German. PubMed PMID: 19358082.

13: Hanlon JT, Aspinall SL, Semla TP, Weisbord SD, Fried LF, Good CB, Fine MJ, Stone RA, Pugh MJ, Rossi MI, Handler SM. Consensus guidelines for oral dosing of primarily renally cleared medications in older adults. J Am Geriatr Soc. 2009 Feb;57(2):335-40. doi: 10.1111/j.1532-5415.2008.02098.x. Epub 2008 Dec 10. Erratum in: J Am Geriatr Soc. 2009 Nov;57(11):2179. Dosage error in article text. PubMed PMID: 19170784; PubMed Central PMCID: PMC2640432.

14: Yarlagadda SG, Perazella MA. Drug-induced crystal nephropathy: an update. Expert Opin Drug Saf. 2008 Mar;7(2):147-58. doi: 10.1517/14740338.7.2.147 . Review. PubMed PMID: 18324877.

15: Padilla MC, Armas-Hernández MJ, Hernández RH, Israili ZH, Valasco M. Update of diuretics in the treatment of hypertension. Am J Ther. 2007 Mar-Apr;14(2):154-60. Review. PubMed PMID: 17414583.

16: Servais A, Daudon M, Knebelman B. [Drug-induced renal calculi]. Ann Urol (Paris). 2006 Apr;40(2):57-68. Review. French. PubMed PMID: 16709005.

17: Ohta A, Sasaki S. [Liddle syndrome: Pathogenesis, pathophysiology, and therapy]. Nihon Rinsho. 2006 Feb;64 Suppl 2:513-6. Review. Japanese. PubMed PMID: 16523945.

18: Cugini P, Lucia P. [Circadian rhythm of the renin-angiotensin-aldosterone system: a summary of our research studies]. Clin Ter. 2004 Jul-Aug;155(7-8):287-91. Review. Italian. PubMed PMID: 15553256.

19: Daudon M, Jungers P. Drug-induced renal calculi: epidemiology, prevention and management. Drugs. 2004;64(3):245-75. Review. PubMed PMID: 14871169.

20: Paul RV. Rational diuretic management in congestive heart failure: a case-based review. Crit Care Nurs Clin North Am. 2003 Dec;15(4):453-60. Review. PubMed PMID: 14717390.

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