WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206627
CAS#: 76123-41-6
Description: GYKI-13324 is bifunctional nitrosoureido derivative and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors.
Hodoodo Cat#: H206627
Name: GYKI-13324
CAS#: 76123-41-6
Chemical Formula: C10H18Cl2N6O6
Exact Mass: 388.07
Molecular Weight: 389.190
Elemental Analysis: C, 30.86; H, 4.66; Cl, 18.22; N, 21.59; O, 24.67
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Synonym: GYKI-13324; GYKI 13324; GYKI13324.
IUPAC/Chemical Name: N-(2-Chloroethyl)-N'-(4-((((2-chloroethyl)amino)carbonyl)nitrosamino)-2,3-dihydroxybutyl)-N-nitrosourea
InChi Key: UYXBAEBEXLEPKR-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H18Cl2N6O6/c11-1-3-13-9(21)18(16-24)6-8(20)7(19)5-14-10(22)17(15-23)4-2-12/h7-8,19-20H,1-6H2,(H,13,21)(H,14,22)
SMILES Code: O=C(NCC(O)C(O)CN(C(NCCCl)=O)N=O)N(CCCl)N=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 389.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Pál K, Kopper L, Lapis K. Chemotherapeutic sensitivity of liver metastases
from intrasplenically-growing Lewis lung tumor. Clin Exp Metastasis. 1983
Oct-Dec;1(4):341-7. PubMed PMID: 6443744.
2: Kopper L, Lapis K, Csányi E, Horváth T. Effect of a new bifunctional
nitrosoureido derivative on human colorectal tumor xenografts. Anticancer Res.
1981;1(4):229-33. PubMed PMID: 7345967.
3: Csányi E, Horváth T, Király E, Lapis K, Kopper L. New type bifunctional
nitrosoureido derivatives with cytostatic activity. Oncology. 1980;37 Suppl
1:59-66. PubMed PMID: 7454201.