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Tiratricol
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H326627

CAS#: 51-24-1

Description: Tiratricol, also known as TRIAC or triiodothyroacetic acid, is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations. Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.

Chemical Structure

Tiratricol

CAS# 51-24-1

Instruction

Theoretical Analysis

Hodoodo Cat#: H326627
Name: Tiratricol
CAS#: 51-24-1
Chemical Formula: C14H9I3O4
Exact Mass: 621.76
Molecular Weight: 621.935
Elemental Analysis: C, 27.04; H, 1.46; I, 61.21; O, 10.29

Price and Availability

Size	Price	Availability
500mg	USD 450	2 Weeks
1g	USD 850	2 Weeks
2g	USD 1450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Tiratricol; TRIAC; triiodothyroacetic acid.

IUPAC/Chemical Name: 2-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)acetic acid

InChi Key: UOWZUVNAGUAEQC-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)

SMILES Code: O=C(O)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 621.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cohen-Lehman J, Charitou MM, Klein I. Tiratricol-induced periodic paralysis: a review of nutraceuticals affecting thyroid function. Endocr Pract. 2011 Jul-Aug;17(4):610-5. doi: 10.4158/EP10137.RA. Review. PubMed PMID: 21803722.

2: Cascales L, Mas-Moruno C, Tamborero S, Aceña JL, Sanz-Cervera JF, Fustero S, Cruz LJ, Mora P, Albericio F, Pérez-Payá E. Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell. Chem Biol Drug Des. 2008 Oct;72(4):320-8. doi: 10.1111/j.1747-0285.2008.00703.x. PubMed PMID: 18844678.

3: Ma RC, Chan MH, Poon WT, So WY, Chow CC. Thyroid dysfunction due to over-the-counter usage of tiratricol. Intern Med J. 2008 Jul;38(7):611-2. doi: 10.1111/j.1445-5994.2008.01708.x. PubMed PMID: 18715309.

4: Ephedrine and tiratricol: freshly prepared mixtures forbidden in France. Prescrire Int. 2004 Apr;13(70):58. PubMed PMID: 15148977.

5: Scally MC, Hodge A. A report of hypothyroidism induced by an over-the-counter fat loss supplement (Tiratricol). Int J Sport Nutr Exerc Metab. 2003 Mar;13(1):112-6. PubMed PMID: 12660410.

6: Bauer BA, Elkin PL, Erickson D, Klee GG, Brennan MD. Symptomatic hyperthyroidism in a patient taking the dietary supplement tiratricol. Mayo Clin Proc. 2002 Jun;77(6):587-90. PubMed PMID: 12059130.

7: Sherman SI, Ringel MD, Smith MJ, Kopelen HA, Zoghbi WA, Ladenson PW. Augmented hepatic and skeletal thyromimetic effects of tiratricol in comparison with levothyroxine. J Clin Endocrinol Metab. 1997 Jul;82(7):2153-8. PubMed PMID: 9215287.

8: Sherman SI, Ladenson PW. Organ-specific effects of tiratricol: a thyroid hormone analog with hepatic, not pituitary, superagonist effects. J Clin Endocrinol Metab. 1992 Sep;75(3):901-5. PubMed PMID: 1517383.

9: Archambeaud-Mouveroux F, Treves R, Veira JC, Laurent M. [Side-effects of tiratricol. Apropos of 4 cases]. Therapie. 1986 Nov-Dec;41(6):519-20. French. PubMed PMID: 3810549.

10: Jean-Pastor MJ, Jean P, Biour M, Castot A, Chichmanian F, Danan G, Levy VG, Sarles H. [Hepatopathies from treatment with a specialty drug combination of tiratricol-cyclovalone-retinol]. J Toxicol Clin Exp. 1986 Mar-Apr;6(2):115-21. French. PubMed PMID: 3783484.

11: Hazard J, Perlemuter L. [Triiodothyronine thyrotoxicosis following the ingestion of a high dose of tiratricol tablets]. Presse Med. 1984 May 12;13(20):1275-6. French. PubMed PMID: 6232590.