WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H326634
CAS#: 35523-45-6
Description: Fludalanine, also known as MK641, is an analogue of D-alanine that irreversibly inactivates the racemase. Fludalanine inhibits the synthetase. When combined with cycloserine, it has been found to be more active against a wide range of non-mycobacterial organisms than either fludalanine or cycloserine alone.
Hodoodo Cat#: H326634
Name: Fludalanine
CAS#: 35523-45-6
Chemical Formula: C3H5DFNO2
Exact Mass: 108.04
Molecular Weight: 108.091
Elemental Analysis: C, 33.34; H, 6.53; F, 17.58; N, 12.96; O, 29.60
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Synonym: MK641; MK641; MK641; Fludalanine; 3-Fluoro-D-(2-2H)alanine; D-Alanine-2-d, 3-fluoro-.
IUPAC/Chemical Name: (S)-2-amino-3-fluoropropanoic-2-d acid
InChi Key: UYTSRQMXRROFPU-LIIDHCAMSA-N
InChi Code: InChI=1S/C3H6FNO2/c4-1-2(5)3(6)7/h2H,1,5H2,(H,6,7)/t2-/m1/s1/i2D
SMILES Code: N[C@@](CF)([2H])C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 108.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Musson DG, Maglietto SM, Hwang SS, Gravellese D, Bayne WF. Simultaneous
quantification of cycloserine and its prodrug acetylacetonylcycloserine in plasma
and urine by high-performance liquid chromatography using ultraviolet absorbance
and fluorescence after post-column derivatization. J Chromatogr. 1987 Feb
20;414(1):121-9. PubMed PMID: 3571377.
2: Darland GK, Hajdu R, Kropp H, Kahan FM, Walker RW, Vandenheuvel WJ. Oxidative
and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine. Drug Metab
Dispos. 1986 Nov-Dec;14(6):668-73. PubMed PMID: 2877824.
3: Dickinson JM, Mitchison DA. Activity of the combination of fludalanine and
cycloserine against mycobacteria in vitro. Tubercle. 1985 Jun;66(2):109-15.
PubMed PMID: 4024268.
4: Musson DG, Maglietto SM, Bayne WF. Determination of the antibiotic fludalanine
in plasma and urine by high-performance liquid chromatography using a packed-bed,
post-column reactor with o-phthalaldehyde and 2-mercaptoethanol. J Chromatogr.
1985 Mar 22;338(2):357-67. PubMed PMID: 3998023.
5: Wise R, Andrews JM. In vitro activity of fludalanine combined with pentizidone
compared with those of other agents. Antimicrob Agents Chemother. 1984
May;25(5):612-7. PubMed PMID: 6610389; PubMed Central PMCID: PMC185598.
6: Esposito AL, Pennington JE. Experimental pneumonia due to Haemophilus
influenzae: observations on pathogenesis and treatment. J Infect Dis. 1984
May;149(5):728-34. PubMed PMID: 6610002.