WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524274
CAS#: 851389-35-0 (ASP-4000)
Description: ASP-4000 HCl is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity.
Hodoodo Cat#: H524274
Name: ASP-4000 HCl
CAS#: 851389-35-0 (ASP-4000)
Chemical Formula: C12H18ClN3O2
Exact Mass: 271.11
Molecular Weight: 271.740
Elemental Analysis: C, 53.04; H, 6.68; Cl, 13.05; N, 15.46; O, 11.78
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: ASP-4000 HCl; ASP 4000 HCl; ASP4000 HCl; UNII-7393JFE67B;
IUPAC/Chemical Name: (2S)-1-(((1R,3S,4S,6R)-6-Hydroxy-2-azabicyclo(2.2.1)hept-3-yl)carbonyl)-2-pyrrolidinecarbonitrile hydrochloride
InChi Key: HBURXUXZLKNVTI-QSWPLQKNSA-N
InChi Code: InChI=1S/C12H17N3O2.ClH/c13-6-8-2-1-3-15(8)12(17)11-7-4-9(14-11)10(16)5-7;/h7-11,14,16H,1-5H2;1H/t7-,8-,9+,10+,11-;/m0./s1
SMILES Code: C1C[C@H](N(C1)C(=O)[C@@H]2[C@H]3C[C@@H](N2)[C@@H](C3)O)C#N.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related: 851389-35-0 (ASP-4000) 851510-67-3 (ASP-4000 free base)
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 271.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Tanaka-Amino K, Hatakeyama Y, Takakura S, Mutoh S. Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats. Pharmacol Res. 2009 Oct;60(4):264-9. doi: 10.1016/j.phrs.2009.03.018. Epub 2009 Apr 7. PubMed PMID: 19520592.
2: Tanaka-Amino K, Matsumoto K, Hatakeyama Y, Takakura S, Mutoh S. ASP4000, a slow-binding dipeptidyl peptidase 4 inhibitor, has antihyperglycemic activity of long duration in Zucker fatty rats. Acta Diabetol. 2010 Mar;47(1):43-8. doi: 10.1007/s00592-009-0096-5. Epub 2009 Feb 24. PubMed PMID: 19238312.
3: Tanaka-Amino K, Matsumoto K, Hatakeyama Y, Shima I, Takakura S, Muto S. ASP4,000, a novel, selective, dipeptidyl peptidase 4 inhibitor with antihyperglycemic activity. Eur J Pharmacol. 2008 Aug 20;590(1-3):444-9. doi: 10.1016/j.ejphar.2008.05.034. Epub 2008 Jun 24. PubMed PMID: 18582861.
