WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524620
CAS#: 81059-04-3
Description: CGP 20376 is a benzothiazole compound which has antifilarial properties.
Hodoodo Cat#: H524620
Name: CGP 20376
CAS#: 81059-04-3
Chemical Formula: C16H20N2O3S3
Exact Mass: 384.06
Molecular Weight: 384.540
Elemental Analysis: C, 49.97; H, 5.24; N, 7.28; O, 12.48; S, 25.02
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: CGP 20376; CGP20376; CGP-20376.
IUPAC/Chemical Name: Propanoic acid, 3-((((2-(1,1-dimethylethyl)-5-methoxy-6-benzothiazolyl)amino)thioxomethyl)thio)-
InChi Key: SGSGNVTYYAWSKN-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H20N2O3S3/c1-16(2,3)14-17-10-7-11(21-4)9(8-12(10)24-14)18-15(22)23-6-5-13(19)20/h7-8H,5-6H2,1-4H3,(H,18,22)(H,19,20)
SMILES Code: COc1cc2nc(sc2cc1NC(=S)SCCC(=O)O)C(C)(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 384.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Renz A, Trees AJ, Achu-Kwi D, Edwards G, Wahl G. Evaluation of suramin, ivermectin and CGP 20376 in a new macrofilaricidal drug screen, Onchocerca ochengi in African cattle. Trop Med Parasitol. 1995 Mar;46(1):31-7. PubMed PMID: 7631125.
2: Tischendorf FW, Brattig NW, Hoyer A, Medina-De la Garza CE, Geisinger F. Modulatory effects of antifilarial drugs ivermectin, CGP 6140 and CGP 20376 on the oxidative burst of eosinophilic granulocytes. Acta Trop. 1993 Mar;53(1):27-37. PubMed PMID: 8096107.
3: Chandrashekar R, Subrahmanyam D, Weil GJ. Effect of CGP 20376 on Brugia malayi and parasite antigenemia in jirds. J Parasitol. 1991 Jun;77(3):479-82. PubMed PMID: 2040959.
4: Mak JW, Suresh K, Lam PL, Choong MF, Striebel HP. Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata. Trop Med Parasitol. 1990 Mar;41(1):10-2. PubMed PMID: 2339241.
5: Strote G. Electron microscopic studies on the effects of CGP 6140 and CGP 20376 on microfilariae and third stage larvae of Onchocerca volvulus. Trop Med Parasitol. 1989 Sep;40(3):304-10. PubMed PMID: 2617038.
6: Weber P. Effects of the two new anthelmintic agents CGP 6140 and CGP 20376 on adult Paragonimus uterobilateralis in the experimental host Sigmodon hispidus. Trop Med Parasitol. 1987 Dec;38(4):335-6. PubMed PMID: 3327145.
7: Strote G. In vitro study on the effect of the new chemotherapeutic agents CGP 6140 and CGP 20376 on the microfilariae of Onchocerca volvulus. Trop Med Parasitol. 1987 Sep;38(3):211-3. PubMed PMID: 3432958.
