WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524634
CAS#: 146388-56-9
Description: Cgp 43487 is a N-methyl-D-aspartate (NMDA) receptor antagonist. The competitive NMDA receptor antagonist, Cgp 43487, was able to elevate the convulsive threshold significantly.
Hodoodo Cat#: H524634
Name: Cgp 43487
CAS#: 146388-56-9
Chemical Formula: C8H16NO5P
Exact Mass: 237.08
Molecular Weight: 237.190
Elemental Analysis: C, 40.51; H, 6.80; N, 5.91; O, 33.73; P, 13.06
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Synonym: Cgp 43487; Cgp43487; Cgp-43487.
IUPAC/Chemical Name: (R,E)-(4-amino-5-ethoxy-2-methyl-5-oxopent-2-en-1-yl)phosphonic acid
InChi Key: OKDOWCKDTWNRCB-PTYLAXBQSA-N
InChi Code: InChI=1S/C8H16NO5P/c1-3-14-8(10)7(9)4-6(2)5-15(11,12)13/h4,7H,3,5,9H2,1-2H3,(H2,11,12,13)/b6-4+/t7-/m1/s1
SMILES Code: CCOC(=O)[C@@H](/C=C(\C)/CP(=O)(O)O)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 237.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gasior M, Borowicz K, Starownik R, Kleinrok Z, Czuczwar SJ. Ca2+ channel blockade and the antielectroshock activity of NMDA receptor antagonists, CGP 40116 and CGP 43487, in mice. Eur J Pharmacol. 1996 Sep 19;312(1):27-33. PubMed PMID: 8891575.
2: Dall'Olio R, Rimondini R, Gandolfi O. The competitive NMDA antagonists CGP 43487 and APV potentiate dopaminergic function. Psychopharmacology (Berl). 1995 Apr;118(3):310-5. PubMed PMID: 7617824.