WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H406753
CAS#: 113942-30-6
Description: Temozolomide Acid, also known as TMZA, is a metabolite of temozolomide (TMZ) with demonstrable anticancer activity in vitro. Temozolomide, (TMZ) (brand names Temodar and Temodal and Temcad) is an oral chemotherapy drug. It is an alkylating agent used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.
Hodoodo Cat#: H406753
Name: Temozolomide Acid
CAS#: 113942-30-6
Chemical Formula: C6H5N5O3
Exact Mass: 195.04
Molecular Weight: 195.138
Elemental Analysis: C, 36.93; H, 2.58; N, 35.89; O, 24.60
Synonym: Temozolomide Acid; TMZA
IUPAC/Chemical Name: 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid
InChi Key: VVTMIOYTNALQAW-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H5N5O3/c1-10-6(14)11-2-7-3(5(12)13)4(11)8-9-10/h2H,1H3,(H,12,13)
SMILES Code: O=C(C1=C(N2C=N1)N=NN(C)C2=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 195.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Suppasansatorn P, Nimmannit U, Conway BR, Du L, Wang Y. Microemulsions as
topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester
(TMZA-HE). J Pharm Pharmacol. 2007 Jun;59(6):787-94. PubMed PMID: 17637171.
