Clioxanide

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H524757

CAS#: 14437-41-3

Description: Clioxanide is an anthelmintic agent.

Chemical Structure

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Clioxanide
CAS# 14437-41-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H524757
Name: Clioxanide
CAS#: 14437-41-3
Chemical Formula: C15H10ClI2NO3
Exact Mass: 540.84
Molecular Weight: 541.510
Elemental Analysis: C, 33.27; H, 1.86; Cl, 6.55; I, 46.87; N, 2.59; O, 8.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Clioxanide; Tremerad; SYD 230; Clioxanidum [INN-Latin]; Clioxanida [INN-Spanish]; SYD-230; EINECS 238-414-0.

IUPAC/Chemical Name: 2-(4-Chlorphenylcarbamoyl)-4,6-diodphenyl acetat

InChi Key: ICKMASVVMCGZLR-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10ClI2NO3/c1-8(20)22-14-12(6-10(17)7-13(14)18)15(21)19-11-4-2-9(16)3-5-11/h2-7H,1H3,(H,19,21)

SMILES Code: c1(c(c(cc(c1)I)I)OC(C)=O)C(Nc1ccc(Cl)cc1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 541.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Douch PG. The metabolism of the anthelmintics clioxanide and resorantel and related compounds in vitro by Moniezia expansa, Ascaris suum and mouse- and sheep-liver enzymes. Xenobiotica. 1979 Apr;9(4):263-8. PubMed PMID: 483862.

2: Foreyt WJ, Todd AC. Effects of six fasciolicides against Fascioloides magna In white-tailed deer. J Wildl Dis. 1976 Jul;12(3):361-6. PubMed PMID: 16498878.

3: Campbell NJ, Brotowidjoyo MD. The efficiency of clioxanide and rafoxanide against Fasciola hepatica in sheep by different routes of administration. Aust Vet J. 1975 Nov;51(11):500-3. PubMed PMID: 1220653.

4: Presidente PJ, Knapp SE, Schlegel MW, Armstrong JN. Anthelmintic efficacy of clioxanide against experimentally induced Fasciola hepatica infections in calves. Am J Vet Res. 1972 Aug;33(8):1593-601. PubMed PMID: 5047118.

5: Campbell NJ, Hotson IK. The anthelmintic efficiency of clioxanide and rafoxanide against Fasciola hepatica and Haemonchus contortus in sheep. Aust Vet J. 1971 Jan;47(1):5-8. PubMed PMID: 5542375.

6: Pearson IG, Whitlock HV, DeGoosh CP, Farrington KJ, Jones RC, Haigh JA. Clioxanide, a new anthelmintic active against Fasciola hepatica and Haemonchus contortus in sheep. Aust Vet J. 1970 Oct;46(10):480-4. PubMed PMID: 5481928.

7: Symons LE, Roseby FB. The use of clioxanide as an anthelmintic in sheep infected with Haemonchus contortus. Aust Vet J. 1969 Aug;45(8):385. PubMed PMID: 5389344.

8: Boray JC, Roseby FB. The effect of the route of administration on the efficiency of clioxanide against immature Fasciola hepatica in sheep. Aust Vet J. 1969 Aug;45(8):363-5. PubMed PMID: 5389338.

9: Tewari HC. Comparative efficiency of hexachloroethane and clioxanide against Fasciola hepatica in the rat. Aust Vet J. 1968 Sep;44(9):401-2. PubMed PMID: 5681445.