WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524759
CAS#: 60200-06-8
Description: Clorsulon is antihelminthic compound that is a potent fasciolicide. Clorsulon targets phosphoglycerate mutase and phosphoglycerate kinase. Clorsulon also discriminates between highly similar host and parasite enzymes.
Hodoodo Cat#: H524759
Name: Clorsulon
CAS#: 60200-06-8
Chemical Formula: C8H8Cl3N3O4S2
Exact Mass: 378.90
Molecular Weight: 380.660
Elemental Analysis: C, 25.24; H, 2.12; Cl, 27.94; N, 11.04; O, 16.81; S, 16.85
Synonym: Clorsulon; Clorsulone; Clorsulonum; BRN 2821757; BRN2821757; BRN-2821757; L-631,529; L631,529; L 631,529; MK 401; MK-401; MK401
IUPAC/Chemical Name: 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide
InChi Key: QOVTVIYTBRHADL-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18)
SMILES Code: c1(c(cc(S(N)(=O)=O)c(c1)N)S(N)(=O)=O)\C(=C(/Cl)Cl)Cl
Appearance: White to off-white solid powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 380.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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2: Kumar R, Doharey PK, Saxena JK, Rathaur S. Molecular cloning, purification and characterization of Brugia malayi phosphoglycerate kinase. Protein Expr Purif. 2017 Apr;132:152-163. doi: 10.1016/j.pep.2017.02.005. Epub 2017 Feb 10. PubMed PMID: 28192198.
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4: Saad AS, Ismail NS, Soliman M, Zaazaa HE. Validated Stability-Indicating RP-HPLC Method for Simultaneous Determination of Clorsulon and Ivermectin Employing Plackett-Burman Experimental Design for Robustness Testing. J AOAC Int. 2016 Mar-Apr;99(2):571-8. doi: 10.5740/jaoacint.15-0128. Epub 2016 Mar 18. PubMed PMID: 26997479.
5: Timson DJ. Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets. Curr Protein Pept Sci. 2016;17(3):280-95. Review. PubMed PMID: 26983888.
6: Elliott TP, Kelley JM, Rawlin G, Spithill TW. High prevalence of fasciolosis and evaluation of drug efficacy against Fasciola hepatica in dairy cattle in the Maffra and Bairnsdale districts of Gippsland, Victoria, Australia. Vet Parasitol. 2015 Apr 15;209(1-2):117-24. doi: 10.1016/j.vetpar.2015.02.014. Epub 2015 Feb 23. PubMed PMID: 25771931.
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9: Martínez-Valladares M, Cordero-Pérez C, Rojo-Vázquez FA. Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon. Exp Parasitol. 2014 Jan;136:59-62. doi: 10.1016/j.exppara.2013.10.010. Epub 2013 Nov 6. PubMed PMID: 24211419.
10: Robles-Pérez D, Martínez-Pérez JM, Rojo-Vázquez FA, Martínez-Valladares M. The diagnosis of fasciolosis in feces of sheep by means of a PCR and its application in the detection of anthelmintic resistance in sheep flocks naturally infected. Vet Parasitol. 2013 Oct 18;197(1-2):277-82. doi: 10.1016/j.vetpar.2013.05.006. Epub 2013 May 14. PubMed PMID: 23743420.
11: Kang YP, Yu J, Huh Y, Oh JH, Kwon CH, Lee SJ, Ee JW, Kim GT, Lee JG, Lee J, Park JH, Kim YS, Kwon SW. Development of high performance liquid chromatography-ultraviolet detection method for screening mebendazole, clorsulon, diaveridine, and tolfenamic acid in animal-based food samples. Drug Test Anal. 2014 Mar;6(3):246-56. doi: 10.1002/dta.1467. Epub 2013 Apr 10. PubMed PMID: 23576386.
12: Richter D, Richter J, Grüner B, Kranz K, Franz J, Kern P. In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis. Parasitol Res. 2013 Apr;112(4):1655-60. doi: 10.1007/s00436-013-3321-7. Epub 2013 Feb 28. PubMed PMID: 23455934.
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14: Geurden T, Bartram D, Van Brussel L, Bo L, Scott-Baird E, Rugg D. Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle. Vet Parasitol. 2012 Oct 26;189(2-4):227-32. doi: 10.1016/j.vetpar.2012.04.019. Epub 2012 Apr 20. PubMed PMID: 22579500.
15: Escribano M, San Andrés MI, de Lucas JJ, González-Canga A. Ivermectin residue depletion in food producing species and its presence in animal foodstuffs with a view to human safety. Curr Pharm Biotechnol. 2012 May;13(6):987-98. Review. PubMed PMID: 22039793.
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17: Cruz-Mendoza I, Quiroz-Romero H, Correa D, Gómez-Espinoza G. Transmission dynamics of Fasciola hepatica in the Plateau Region of Mexico. Effect of weather and treatment of mammals under current farm management. Vet Parasitol. 2011 Jan 10;175(1-2):73-9. doi: 10.1016/j.vetpar.2010.09.034. Epub 2010 Oct 8. PubMed PMID: 21055879.
18: Dupuy J, Alvinerie M, Ménez C, Lespine A. Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells. Chem Biol Interact. 2010 Aug 5;186(3):280-6. doi: 10.1016/j.cbi.2010.05.013. Epub 2010 Jun 1. PubMed PMID: 20513441.
19: Hutchinson GW, Dawson K, Fitzgibbon CC, Martin PJ. Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle. Vet Parasitol. 2009 Jun 10;162(3-4):278-84. doi: 10.1016/j.vetpar.2009.03.032. Epub 2009 Mar 27. PubMed PMID: 19375232.
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