WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526502
CAS#: 68-76-8
Description: Triaziquone is an alkylating agent that can react with DNA to form intrastrand crosslinks.
Hodoodo Cat#: H526502
Name: Triaziquone
CAS#: 68-76-8
Chemical Formula: C12H13N3O2
Exact Mass: 231.10
Molecular Weight: 231.255
Elemental Analysis: C, 62.33; H, 5.67; N, 18.17; O, 13.84
This product is not in stock, which may be available by custom synthesis.
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Synonym: A 163; A 163; A 163; Triaziquone; Trenimon; Trenimone; Triazichon
IUPAC/Chemical Name: 2,3,5-tri(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione
InChi Key: PXSOHRWMIRDKMP-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H13N3O2/c16-9-7-8(13-1-2-13)12(17)11(15-5-6-15)10(9)14-3-4-14/h7H,1-6H2
SMILES Code: O=C(C(N1CC1)=C2N3CC3)C=C(N4CC4)C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 231.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lin YL, Su YT, Chen BH. A study on inhibition mechanism of breast cancer cells by bis-type triaziquone. Eur J Pharmacol. 2010 Jul 10;637(1-3):1-10. doi: 10.1016/j.ejphar.2010.03.034. Epub 2010 Apr 2. PubMed PMID: 20371239.
2: Huang CH, Kuo HS, Liu JW, Lin YL. Synthesis and antitumor evaluation of novel bis-triaziquone derivatives. Molecules. 2009 Jun 29;14(7):2306-16. doi: 10.3390/molecules14072306. PubMed PMID: 19633605.
3: Oud JL, de Jong JH, de Rooij DG. A sequential analysis of meiosis in the male mouse using a restricted spermatocyte population obtained by a hydroxyurea/triaziquone treatment. Chromosoma. 1979 Feb 21;71(2):237-48. PubMed PMID: 371933.
4: Oud JL, Peters PW. A sequential screening of the cytogenetic damage induced by triaziquone. Mutat Res. 1978 Oct;54(2):175-84. PubMed PMID: 362189.
5: Linford JH, Froese G. Comparisons of the chemical and biologic properties of triaziquone and triaziquone-protein conjugates. J Natl Cancer Inst. 1978 Feb;60(2):307-16. PubMed PMID: 74416.
6: Vogel W, Bauknecht T. Effects of caffeine on sister chromatid exchange (SCE) after exposure to UV light or triaziquone studied with a fluorescence plus giemsa (FPG) technique. Hum Genet. 1978 Jan 19;40(2):193-8. PubMed PMID: 624547.
7: Hansmann I, Neher J, Röhrborn G. Chromosome aberrations in metaphase II oocytes of Chinese hamster (Cricetulus griseus). I. The sensitivity of the pre-ovulatory phase to triaziquone. Mutat Res. 1974 Dec;25(3):347-59. PubMed PMID: 4437573.
8: Machemer L, Hess R. Induced dominant lethals in female mice: effects of triaziquone and phenylbutazone. Experientia. 1973 Feb 15;29(2):190-2. PubMed PMID: 4692764.
9: Norpoth K, Modlich W, Schumacher H, Rauen HM. [Comparative studies using the urine metabolites of cyclophosphamide, bis-(2-chloroethyl)amine and triaziquone on Lactobacillus fermenti ATCC 9338]. Arzneimittelforschung. 1972 Oct;22(10):1784-8. German. PubMed PMID: 4677072.
10: Machemer L, Stenger EG. [Study on the reproducibility of the dominant lethal test in the mouse using cyclophosphamide and triaziquone]. Arzneimittelforschung. 1971 Jul;21(7):1037-9. German. PubMed PMID: 5109493.
11: Albert R. [Therapeutic effect of progesterone-bis-guanylhydrazone on rat mammary tumors and on the mouse in comparison to triaziquone (Trenimon) and cyclophosphamide]. Pharmazie. 1967 Oct;22(10):603. German. PubMed PMID: 5602426.
