WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525640
CAS#: 42794-63-8
Description: MK-142 dimethanesulfonate is a bioactive agent with antiarrhythmic properties. The relatively high content of MK-142 in the myocardium as compared with its content in the skeletal muscles indicates a high affinity of the examined substance to the heart muscle. MK-142 is excreted via kidneys, alimentary tract and respiratory ways.
Hodoodo Cat#: H525640
Name: MK-142 dimethanesulfonate
CAS#: 42794-63-8
Chemical Formula: C22H32N2O6
Exact Mass: 420.23
Molecular Weight: 420.506
Elemental Analysis: C, 62.84; H, 7.67; N, 6.66; O, 22.83
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Synonym: MK142; MK-142; MK 142
IUPAC/Chemical Name: 3,3'-(ethane-1,2-diylbis(azanediyl))bis(1-(4-methoxyphenoxy)propan-2-ol)
InChi Key: ZVXXHYUUXAYZPB-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H32N2O6/c1-27-19-3-7-21(8-4-19)29-15-17(25)13-23-11-12-24-14-18(26)16-30-22-9-5-20(28-2)6-10-22/h3-10,17-18,23-26H,11-16H2,1-2H3
SMILES Code: OC(COC1=CC=C(OC)C=C1)CNCCNCC(O)COC2=CC=C(OC)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 420.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Noyszewska-Skibińska I, Nowicka A, Ernest K, Nowicka J. Biochemical, morphochemical and pharmacodynamic evaluation of accumulation of ethylenediamine derivatives (ROM-203, MK-142) in some rat tissues. Mater Med Pol. 1977 Jul-Sep;9(3):216-24. PubMed PMID: 926836.
2: Ernest K. Pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part II. Antiarrhythmic properties, the influence on heart and some hemodynamic parameters. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):381-98. PubMed PMID: 1166019.
3: Ernest K. The pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part I. General pharmacological properties. Pol J Pharmacol Pharm. 1975 Jul-Aug;27(4):363-79. PubMed PMID: 241067.
4: Nowicka A, Prussak T, Szukalski B. Metabolism of some ethylenediamine derivatives with antiarrhythmic properties. I. Absorption, distribution in tissues and excretion of 14-C labelled N, N'-bis-[3-(p-methoxyphenoxy)-2-hydroxypropyl]-ethylenediamine dimethanesulphonate (MK-142) in rats. Pol J Pharmacol Pharm. 1975 Apr-Jun;27(2):113-20. PubMed PMID: 168561.
