WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524810
CAS#: 91896-57-0
Description: CP-66713 is an adenosine A2 receptor antagonist.
Hodoodo Cat#: H524810
Name: CP 66713
CAS#: 91896-57-0
Chemical Formula: C15H10ClN5
Exact Mass: 295.06
Molecular Weight: 295.730
Elemental Analysis: C, 60.92; H, 3.41; Cl, 11.99; N, 23.68
Synonym: CP 66713; CP-66713; CP66713.
IUPAC/Chemical Name: (1,2,4)Triazolo(4,3-a)quinoxalin-4-amine, 8-chloro-1-phenyl-
InChi Key: PBENJWAFQLORQL-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H10ClN5/c16-10-6-7-11-12(8-10)21-14(9-4-2-1-3-5-9)19-20-15(21)13(17)18-11/h1-8H,(H2,17,18)
SMILES Code: c1(cc2c(cc1)nc(N)c1nnc(n21)c1ccccc1)Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 295.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fujii S, Kato H, Ito K, Itoh S, Yamazaki Y, Sasaki H, Kuroda Y. Effects of A1 and A2 adenosine receptor antagonists on the induction and reversal of long-term potentiation in guinea pig hippocampal slices of CA1 neurons. Cell Mol Neurobiol. 2000 Jun;20(3):331-50. PubMed PMID: 10789832.
2: Fujii S, Kuroda Y, Ito KL, Yoshioka M, Kaneko K, Yamazaki Y, Sasaki H, Kato H. Endogenous adenosine regulates the effects of low-frequency stimulation on the induction of long-term potentiation in CA1 neurons of guinea pig hippocampal slices. Neurosci Lett. 2000 Jan 28;279(2):121-4. PubMed PMID: 10674636.
3: Fujii S, Kuroda Y, Ito Ki, Kaneko K, Kato H. Effects of adenosine receptors on the synaptic and EPSP-spike components of long-term potentiation and depotentiation in the guinea-pig hippocampus. J Physiol. 1999 Dec 1;521 Pt 2:451-66. PubMed PMID: 10581315; PubMed Central PMCID: PMC2269672.
4: Fredholm BB, Lindström K. Autoradiographic comparison of the potency of several structurally unrelated adenosine receptor antagonists at adenosine A1 and A(2A) receptors. Eur J Pharmacol. 1999 Sep 10;380(2-3):197-202. PubMed PMID: 10513579.
5: O'Kane EM, Stone TW. Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro. Eur J Pharmacol. 1998 Nov 27;362(1):17-25. PubMed PMID: 9865525.
6: Matsugi T, Chen Q, Anderson DR. Adenosine-induced relaxation of cultured bovine retinal pericytes. Invest Ophthalmol Vis Sci. 1997 Dec;38(13):2695-701. PubMed PMID: 9418721.
7: Zhang Y, Raud J, Hedqvist P, Fredholm BB. Propentofylline inhibits polymorphonuclear leukocyte recruitment in vivo by a mechanism involving adenosine A2A receptors. Eur J Pharmacol. 1996 Oct 17;313(3):237-42. PubMed PMID: 8911920.
8: Phillis JW. The effects of selective A1 and A2a adenosine receptor antagonists on cerebral ischemic injury in the gerbil. Brain Res. 1995 Dec 24;705(1-2):79-84. PubMed PMID: 8821736.
9: Suzuki M, Tomaru A, Kishibayashi N, Karasawa A. Effects of the adenosine A1-receptor antagonist on defecation, small intestinal propulsion and gastric emptying in rats. Jpn J Pharmacol. 1995 May;68(1):119-23. PubMed PMID: 7494374.
10: Szentmiklósi AJ, Ujfalusi A, Cseppentö A, Nosztray K, Kovács P, Szabó JZ. Adenosine receptors mediate both contractile and relaxant effects of adenosine in main pulmonary artery of guinea pigs. Naunyn Schmiedebergs Arch Pharmacol. 1995 Apr;351(4):417-25. PubMed PMID: 7543187.
11: Kirkpatrick KA, Richardson PJ. Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes. Br J Pharmacol. 1993 Nov;110(3):949-54. PubMed PMID: 8298819; PubMed Central PMCID: PMC2175826.
12: Vellucci SV, Sirinathsinghji DJ, Richardson PJ. Adenosine A2 receptor regulation of apomorphine-induced turning in rats with unilateral striatal dopamine denervation. Psychopharmacology (Berl). 1993;111(3):383-8. PubMed PMID: 7870978.
13: Fujii S, Wakizaka A, Sekino Y, Kuroda Y, Ito K, Miyakawa H, Kato H. Adenosine A2 receptor antagonist facilitates the reversal of long-term potentiation (depotentiation) of evoked postsynaptic potentials but inhibits that of population spikes in hippocampal CA1 neurons. Neurosci Lett. 1992 Dec 14;148(1-2):148-50. PubMed PMID: 1300488.
14: Fuder H, Brink A, Meincke M, Tauber U. Purinoceptor-mediated modulation by endogenous and exogenous agonists of stimulation-evoked [3H]noradrenaline release on rat iris. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):417-23. PubMed PMID: 1320209.
15: Sekino Y, Ito K, Miyakawa H, Kato H, Kuroda Y. Adenosine (A2) antagonist inhibits induction of long-term potentiation of evoked synaptic potentials but not of the population spike in hippocampal CA1 neurons. Biochem Biophys Res Commun. 1991 Dec 31;181(3):1010-4. PubMed PMID: 1764051.
