WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H326701
CAS#: 77337-73-6 (calcium salt)
Description: Acamprosate is a medication used along with counselling in the treatment of alcohol dependence. Acamprosate is thought to stabilize the chemical balance in the brain that would otherwise be disrupted by alcohol withdrawal. Reports indicate that acamprosate works to best advantage in combination with psychosocial support and can help facilitate reduced consumption as well as full abstinence. Until it became a generic in the United States, Campral was manufactured and marketed in the United States by Forest Laboratories, while Merck KGaA markets it outside the US.
Hodoodo Cat#: H326701
Name: Acamprosate calcium
CAS#: 77337-73-6 (calcium salt)
Chemical Formula: C10H20CaN2O8S2
Exact Mass: 0.00
Molecular Weight: 400.474
Elemental Analysis: C, 29.99; H, 5.03; Ca, 10.01; N, 7.00; O, 31.96; S, 16.01
Related CAS #: 77337-73-6 (calcium salt); 77337-76-9 (free acid).
Synonym: Alcomed; Aotal; Campral; Sobriol; Acamprosate calcium
IUPAC/Chemical Name: Calcium 3-(acetylamino)propane-1-sulfonate
InChi Key: BUVGWDNTAWHSKI-UHFFFAOYSA-L
InChi Code: InChI=1S/2C5H11NO4S.Ca/c2*1-5(7)6-3-2-4-11(8,9)10;/h2*2-4H2,1H3,(H,6,7)(H,8,9,10);/q;;+2/p-2
SMILES Code: O=S(CCCNC(C)=O)([O-])=O.O=S(CCCNC(C)=O)([O-])=O.[Ca+2]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | Acamprosate calcium (Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems. |
In vitro activity: | TBD |
In vivo activity: | This study next investigated whether acamprosate administration affected concentrations of vesicular glutamate and zinc in the hippocampus of intact brain. Immunohistochemical examination of the hippocampal dentate gyrus area showed expression of VGLUT1 or ZnT3 in the vehicle-treated group. In contrast, VGLUT1 or ZnT3 expression was significantly reduced in the acamprosate-treated group at the same hippocampal area (VGLUT1: vehicle, 30.74 ± 2.8; acamprosate, 19.36 ± 1.8, a 37% decrease; ZnT3: vehicle, 24.98 ± 1.25; acamprosate, 19.62 ± 0.36, a 21% decrease; average gray-scale intensities; Fig 1 B, C, F, and G). Western blot also revealed a significant decrease in the level of each of these proteins in the hippocampus of rats receiving acamprosate for 2 weeks as compared with the vehicle-treated group (VGLUT1: 0.48-fold change, P < 0.01; ZnT3: 0.74-fold change, P < 0.01; Fig 1 A–H). Moreover, the vesicular TSQ intensity was also significantly decreased in the hippocampal mossy fibers in rats receiving acamprosate as compared with the vehicle-treated group (vehicle, 24.3 ± 0.68; acamprosate, 19.68 ± 0.81, a 19% decrease; average gray-scale intensities; Fig 1 I–K). Reference: Transl Res. 2019 May;207:1-18. https://pubmed.ncbi.nlm.nih.gov/30731068/ |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 0.5 | 1.25 | |
PBS (pH 7.2) | 1.0 | 2.50 | |
Water | 50.0 | 124.85 |
The following data is based on the product molecular weight 400.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | 1. Choi BY, Lee SH, Choi HC, Lee SK, Yoon HS, Park JB, Chung WS, Suh SW. Alcohol dependence treating agent, acamprosate, prevents traumatic brain injury-induced neuron death through vesicular zinc depletion. Transl Res. 2019 May;207:1-18. doi: 10.1016/j.trsl.2019.01.002. Epub 2019 Jan 17. PMID: 30731068. 2. Chau P, Lidö HH, Söderpalm B, Ericson M. Acamprosate's ethanol intake-reducing effect is associated with its ability to increase dopamine. Pharmacol Biochem Behav. 2018 Dec;175:101-107. doi: 10.1016/j.pbb.2018.09.009. Epub 2018 Sep 26. PMID: 30266455. |
In vitro protocol: | TBD |
In vivo protocol: | 1. Choi BY, Lee SH, Choi HC, Lee SK, Yoon HS, Park JB, Chung WS, Suh SW. Alcohol dependence treating agent, acamprosate, prevents traumatic brain injury-induced neuron death through vesicular zinc depletion. Transl Res. 2019 May;207:1-18. doi: 10.1016/j.trsl.2019.01.002. Epub 2019 Jan 17. PMID: 30731068. 2. Chau P, Lidö HH, Söderpalm B, Ericson M. Acamprosate's ethanol intake-reducing effect is associated with its ability to increase dopamine. Pharmacol Biochem Behav. 2018 Dec;175:101-107. doi: 10.1016/j.pbb.2018.09.009. Epub 2018 Sep 26. PMID: 30266455. |
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