WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524816
CAS#: 108461-05-8
Description: CP 74667 is a new fluoroquinolone that has good activity against several gram-positive and gram-negative pathogens.
Hodoodo Cat#: H524816
Name: CP 74667
CAS#: 108461-05-8
Chemical Formula: C20H22FN3O3
Exact Mass: 371.16
Molecular Weight: 371.410
Elemental Analysis: C, 64.68; H, 5.97; F, 5.12; N, 11.31; O, 12.92
This product is not in stock, which may be available by custom synthesis.
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Synonym: CP 74667; CP74667; CP-74667; UNII-D66A707X1B.
IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(8-methyl-3,8-diazabicyclo(3.2.1)oct-3-yl)-4-oxo-
InChi Key: ALRZZABRVIYCNY-BETUJISGSA-N
InChi Code: InChI=1S/C20H22FN3O3/c1-22-12-4-5-13(22)9-23(8-12)18-7-17-14(6-16(18)21)19(25)15(20(26)27)10-24(17)11-2-3-11/h6-7,10-13H,2-5,8-9H2,1H3,(H,26,27)/t12-,13+
SMILES Code: CN1[C@H]2CC[C@@H]1CN(C2)c3cc4N(C=C(C(=O)O)C(=O)c4cc3F)C5CC5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 371.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Gu JW, Fang W, Chin NX, Neu HC. In vitro activity of CP-74,667. A new fluoroquinolone compared with other quinolones. Diagn Microbiol Infect Dis. 1992 Sep-Oct;15(7):613-20. PubMed PMID: 1330421.
2: Jones RN, Erwin ME. In vitro activity of CP-74667 compared with four other fluoroquinolones. Diagn Microbiol Infect Dis. 1992 Aug;15(6):531-6. PubMed PMID: 1330419.
3: Girard D, Gootz TD, McGuirk PR. Pharmacokinetic studies of CP-74,667, a new quinolone, in laboratory animals. Antimicrob Agents Chemother. 1992 Aug;36(8):1671-6. PubMed PMID: 1329625; PubMed Central PMCID: PMC192028.