WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524832
CAS#: 138047-56-0
Description: CP-283097 is an antagonist of N-methyl-D-aspartate (NMDA) receptors containing the NR2B subunit.
Hodoodo Cat#: H524832
Name: CP-283097
CAS#: 138047-56-0
Chemical Formula: C21H25NO4
Exact Mass: 355.18
Molecular Weight: 355.430
Elemental Analysis: C, 70.96; H, 7.09; N, 3.94; O, 18.01
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Synonym: CP-283097; CP283097; CP 283097; UNII-WHL1Z3GN15;
IUPAC/Chemical Name: (3R,4S)-Rel-3,4-dihydro-3-(4-hydroxy-4-(phenylmethyl)-1-piperidinyl)-2H-1-benzopyran-4,7-diol
InChi Key: JQQWDYJWDCIVKQ-QUCCMNQESA-N
InChi Code: InChI=1S/C21H25NO4/c23-16-6-7-17-19(12-16)26-14-18(20(17)24)22-10-8-21(25,9-11-22)13-15-4-2-1-3-5-15/h1-7,12,18,20,23-25H,8-11,13-14H2/t18-,20+/m1/s1
SMILES Code: c1ccc(cc1)CC2(CCN(CC2)[C@@H]3COc4cc(ccc4[C@@H]3O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 355.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Murray F, Kennedy J, Hutson PH, Elliot J, Huscroft I, Mohnen K, Russell MG, Grimwood S. Modulation of [3H]MK-801 binding to NMDA receptors in vivo and in vitro. Eur J Pharmacol. 2000 Jun 2;397(2-3):263-70. PubMed PMID: 10844123.
2: Butler TW, Blake JF, Bordner J, Butler P, Chenard BL, Collins MA, DeCosta D, Ducat MJ, Eisenhard ME, Menniti FS, Pagnozzi MJ, Sands SB, Segelstein BE, Volberg W, White WF, Zhao D. (3R,4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol. J Med Chem. 1998 Mar 26;41(7):1172-84. PubMed PMID: 9544217.