WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524839
CAS#: 431990-08-8
Description: CP-432, also known as CP-734432, is an EP4 prostaglandin agonist and is potential useful for the treatment of glaucoma and ocular hypertension.
Hodoodo Cat#: H524839
Name: CP-432
CAS#: 431990-08-8
Chemical Formula: C23H26F3NO4S
Exact Mass: 469.15
Molecular Weight: 469.520
Elemental Analysis: C, 58.84; H, 5.58; F, 12.14; N, 2.98; O, 13.63; S, 6.83
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: CP-432; CP 432; CP432; CP-734432; CP 734432; CP734432.
IUPAC/Chemical Name: 2-Thiophenecarboxylic acid, 5-(3-((2S)-2-((3R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxo-1-pyrrolidinyl)propyl)-
InChi Key: JYZXGURJKNAFPT-ZWKOTPCHSA-N
InChi Code: InChI=1S/C23H26F3NO4S/c24-23(25,26)16-4-1-3-15(13-16)14-18(28)8-6-17-7-11-21(29)27(17)12-2-5-19-9-10-20(32-19)22(30)31/h1,3-4,9-10,13,17-18,28H,2,5-8,11-12,14H2,(H,30,31)/t17-,18+/m0/s1
SMILES Code: c1cc(cc(c1)C(F)(F)F)C[C@@H](CC[C@H]2CCC(=O)N2CCCc3ccc(s3)C(=O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 469.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Hu KZ, Ma J, Qiu S, Zheng X, Huang PQ. SmI2-mediated intermolecular coupling
of γ-lactam N-α-radicals with activated alkenes: asymmetric synthesis of
11-hydroxylated analogues of the lead compounds CP-734432 and PF-04475270. J Org
Chem. 2013 Mar 1;78(5):1790-801. doi: 10.1021/jo301277n. Epub 2012 Aug 14. PubMed
PMID: 22853560.
2: Luu KT, Zhang EY, Prasanna G, Xiang C, Anderson S, Fortner J, Vicini P.
Pharmacokinetic-pharmacodynamic and response sensitization modeling of the
intraocular pressure-lowering effect of the EP4 Agonist
5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-
1-yl]propyl}thiophene-2-carboxylate (PF-04475270). J Pharmacol Exp Ther. 2009
Nov;331(2):627-35. doi: 10.1124/jpet.109.157800. Epub 2009 Aug 18. PubMed PMID:
19690190.
3: Prasanna G, Fortner J, Xiang C, Zhang E, Carreiro S, Anderson S, Sartnurak S,
Wu G, Gukasyan H, Niesman M, Nair S, Rui E, Lafontaine J, Almaden CD, Wells P,
Krauss A. Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4
prostaglandin agonist in preclinical models. Exp Eye Res. 2009 Nov;89(5):608-17.
doi: 10.1016/j.exer.2009.05.002. Epub 2009 May 13. PubMed PMID: 19445930.
