WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524848
CAS#: 305821-96-9
Description: CP-472555 is a selective, nonsteroidal glucocorticoid receptor antagonist, with anti-GR and anti-obesity activity in animal models.
Hodoodo Cat#: H524848
Name: CP-472555
CAS#: 305821-96-9
Chemical Formula: C31H32N2O2
Exact Mass: 464.25
Molecular Weight: 464.600
Elemental Analysis: C, 80.14; H, 6.94; N, 6.03; O, 6.89
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Synonym: CP-472555; CP 472555; CP472555; UNII-6T0KV7024R.
IUPAC/Chemical Name: 2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propyn-1-yl)-N-(3-pyridinylmethyl)-, (4bS,7R,8aR)-
InChi Key: SEOPOTXFVGEDGX-UPHHSBJESA-N
InChi Code: InChI=1S/C31H32N2O2/c1-2-14-30(35)15-16-31(19-23-7-4-3-5-8-23)27(20-30)12-10-25-18-26(11-13-28(25)31)29(34)33-22-24-9-6-17-32-21-24/h3-9,11,13,17-18,21,27,35H,10,12,15-16,19-20,22H2,1H3,(H,33,34)/t27-,30-,31+/m1/s1
SMILES Code: CC#C[C@]1(CC[C@]2(c3ccc(cc3CC[C@@H]2C1)C(=O)NCc4cccnc4)Cc5ccccc5)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 464.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Briski KP, Kale AY, Vavaiya KV. Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors. Exp Brain Res. 2009 Jun;195(4):499-507. doi: 10.1007/s00221-009-1787-4. Epub 2009 May 6. PubMed PMID: 19418044.
2: Kale AY, Paranjape SA, Briski KP. Type II glucocorticoid receptor involvement in habituated activation of lateral hypothalamic area orexin-A-immunopositive neurons during recurring insulin-induced hypoglycemia. Neurosci Res. 2006 Nov;56(3):309-13. Epub 2006 Sep 25. PubMed PMID: 16997409.
3: Kale AY, Vavaiya KV, Briski KP. Effects of acute and chronic insulin-induced hypoglycemia on type II glucocorticoid receptor (GR) gene expression in characterized CNS metabolic loci. Brain Res Bull. 2006 Jul 31;70(3):240-4. Epub 2006 Jun 6. PubMed PMID: 16861109.
4: Kale AY, Paranjape SA, Briski KP. Site-specific habituation of insulin-induced hypoglycemic induction of fos immunoreactivity in glucocorticoid receptor: immunopositive neurons in the male rat brain. Exp Brain Res. 2007 Jan;176(2):260-6. PubMed PMID: 16850320.
5: Kale AY, Paranjape SA, Briski KP. I.c.v. administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration. Neuroscience. 2006 Jun 30;140(2):555-65. Epub 2006 Apr 19. PubMed PMID: 16626867.