WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526520
CAS#: 170684-14-7
Description: UK 1745 is a novel cardiotonic drug.
Hodoodo Cat#: H526520
Name: UK 1745
CAS#: 170684-14-7
Chemical Formula: C16H23ClN2O2
Exact Mass: 310.14
Molecular Weight: 310.822
Elemental Analysis: C, 61.83; H, 7.46; Cl, 11.41; N, 9.01; O, 10.29
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Synonym: UK 1745, UK1745, UK-1745
IUPAC/Chemical Name: (2R,3S)-2-(aminomethyl)-2,3,5,8,8-pentamethyl-2,3,6,8-tetrahydro-7H-furo[2,3-e]indol-7-one hydrochloride
InChi Key: XVUOIQVVCCRMAY-SCKAJQSLSA-N
InChi Code: InChI=1S/C16H22N2O2.ClH/c1-8-6-10-9(2)16(5,7-17)20-13(10)11-12(8)18-14(19)15(11,3)4;/h6,9H,7,17H2,1-5H3,(H,18,19);1H/t9-,16-;/m0./s1
SMILES Code: O=C1NC2=C(C(O[C@@](C)(CN)[C@H]3C)=C3C=C2C)C1(C)C.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 310.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Uemura H, Sakamoto N, Nakaya H. Electropharmacological effects of UK-1745, a novel cardiotonic drug, in guinea-pig ventricular myocytes. Eur J Pharmacol. 1999 Nov 3;383(3):361-71. PubMed PMID: 10594330.
2: Sawada H, Endoh M. Pharmacological characterization of effects of UK-1745, a novel cardiotonic agent with beta-adrenoceptor-blocking action, in aequorin-loaded canine right ventricular muscle. J Mol Cell Cardiol. 1999 May;31(5):1047-62. PubMed PMID: 10336843.
3: Uchida Y, Kawada M, Sawanobori K, Sonoki H, Inoue K, Mizuno K, Itou T, Tabunoki Y, Tsukamoto M, Ohashi Y, Kyotani Y, Shimizu N, Fujii M, Nakamura M. Cardiovascular effects of (2RS,3SR)- 2-aminomethyl-2,3,7,8-tetrahydro-2,3,5,8,8-pentamethyl-6H-furo- [2,3-e]indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties. Arzneimittelforschung. 1998 Mar;48(3):219-31. PubMed PMID: 9553677.