WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526526
CAS#: 97290-20-5
Description: UK 55444 is a potent (IC50 = 8 x 10(-9) M) calcium antagonist which is 40-fold selective for vascular over cardiac tissue and which has a significantly longer duration of action (greater than 3 h) than nifedipine in the anesthetized dog on intravenous administration.
Hodoodo Cat#: H526526
Name: UK 55444
CAS#: 97290-20-5
Chemical Formula: C23H26Cl2N4O6
Exact Mass: 524.12
Molecular Weight: 525.383
Elemental Analysis: C, 52.58; H, 4.99; Cl, 13.49; N, 10.66; O, 18.27
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Synonym: UK 55444, UK 55444, UK 55444
IUPAC/Chemical Name: 3-ethyl 5-methyl 2-((2-(2-amino-4-oxo-4,5-dihydro-1H-imidazol-1-yl)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
InChi Key: PWEQUMVRHICAHB-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H26Cl2N4O6/c1-4-35-22(32)19-15(11-34-9-8-29-10-16(30)28-23(29)26)27-12(2)17(21(31)33-3)18(19)13-6-5-7-14(24)20(13)25/h5-7,18,27H,4,8-11H2,1-3H3,(H2,26,28,30)
SMILES Code: O=C(C1=C(COCCN(C(N)=N2)CC2=O)NC(C)=C(C(OC)=O)C1C3=CC=CC(Cl)=C3Cl)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 525.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Alker D, Campbell SF, Cross PE, Burges RA, Carter AJ, Gardiner DG. Long-acting dihydropyridine calcium antagonists. 5. Synthesis and structure-activity relationships for a series of 2-[[(N-substituted-heterocyclyl)ethoxy]methyl]-1,4-dihydropyridine calcium antagonists. J Med Chem. 1990 Jun;33(6):1805-11. PubMed PMID: 2342074.