WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524854
CAS#: 432038-96-5
Description: CP-5609 is a novel carbapenem with enhanced antimicrobial activities.
Hodoodo Cat#: H524854
Name: CP-5609
CAS#: 432038-96-5
Chemical Formula: C23H21N5O6S
Exact Mass: 495.12
Molecular Weight: 495.510
Elemental Analysis: C, 55.75; H, 4.27; N, 14.13; O, 19.37; S, 6.47
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Synonym: CP-5609; CP 5609; CP5609; ME-1036; ME 1036;ME1036; UNII-33501R83O2.
IUPAC/Chemical Name: Pyridinium, 1-(2-amino-2-oxoethyl)-3-((2-((4S,5R,6S)-2-carboxy-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-en-3-yl)imidazo(5,1-b)thiazol-7-yl)carbonyl)-, inner salt
InChi Key: LZKPUSJSJVEXAW-WDXSGGTDSA-N
InChi Code: InChI=1S/C23H21N5O6S/c1-10-15(19(23(33)34)28-18(10)16(11(2)29)21(28)32)13-7-27-9-25-17(22(27)35-13)20(31)12-4-3-5-26(6-12)8-14(24)30/h3-7,9-11,16,18,29H,8H2,1-2H3,(H2-,24,30,33,34)/t10-,11+,16+,18+/m0/s1
SMILES Code: C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1c3cn4cnc(c4s3)C(=O)c5ccc[n+](c5)CC(=O)N)C(=O)[O-])[C@@H](C)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 495.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Hirai Y, Takahata S, Yamada K, Ida T, Maebashi K. Correlation of the antimicrobial activity of ME1036 with its binding affinities to the penicillin-binding proteins from Streptococcus pneumoniae strains. J Antibiot (Tokyo). 2011 Nov;64(11):741-6. doi: 10.1038/ja.2011.76. Epub 2011 Aug 24. PubMed PMID: 21863036.
2: Morrissey I, Biek D, Janes R. ME1036, a novel carbapenem, with enhanced activity against clinical isolates causing bacteraemic community-acquired pneumonia. J Antimicrob Chemother. 2009 Jul;64(1):209-10. doi: 10.1093/jac/dkp163. Epub 2009 May 9. PubMed PMID: 19429928.
3: Yanagihara K, Ohnishi Y, Morinaga Y, Nakamura S, Kurihara S, Seki M, Izumikawa K, Kakeya H, Yamamoto Y, Yamada Y, Kohno S, Kamihira S. Efficacy of ME1036 against meticillin-resistant Staphylococcus aureus and vancomycin-insensitive S. aureus in a model of haematogenous pulmonary infection. Int J Antimicrob Agents. 2008 Nov;32(5):401-4. doi: 10.1016/j.ijantimicag.2008.04.030. Epub 2008 Aug 19. PubMed PMID: 18715761.
4: Fenoll A, Aguilar L, Robledo O, Giménez MJ, Granizo JJ, Biek D, Tarragó D. In vitro activity of ME1036 versus other beta-lactams against penicillin-resistant Streptococcus pneumoniae serotypes exhibiting higher amoxicillin than penicillin MIC. J Antimicrob Chemother. 2008 Nov;62(5):1156-8. doi: 10.1093/jac/dkn314. Epub 2008 Jul 30. PubMed PMID: 18667449.
5: Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, Mobashery S. Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics. J Am Chem Soc. 2008 Jul 23;130(29):9212-3. doi: 10.1021/ja8029448. Epub 2008 Jun 27. PubMed PMID: 18582062; PubMed Central PMCID: PMC2747592.
6: Sader HS, Fritsche TR, Jones RN. Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Mar;52(3):1153-5. doi: 10.1128/AAC.01351-07. Epub 2008 Jan 7. PubMed PMID: 18180353; PubMed Central PMCID: PMC2258508.
7: Dalziel C, Turner B. Interscience conference on antimicrobial agents and chemotherapy--46th annual meeting. Release of data for Dc-159a, and other agents. 27-30 September 2006, San Francisco, CA, USA. IDrugs. 2006 Nov;9(11):765-7. PubMed PMID: 17096295.
8: Nagura J, Kijima K, Kurazono M, Takahata S, Sugano T, Tanaka Y, Hirai Y, Yamada K, Takayama Y, Shitara E, Yonezawa M. Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2005 Aug;49(8):3526-8. PubMed PMID: 16048975; PubMed Central PMCID: PMC1196270.
9: Maeda K, Ida T, Sanbongi Y, Suzuki T, Fukushima T, Kurazono M, Yonezawa M, Ubukata K, Inoue M. Comparison of activities of beta-lactam antibiotics against Streptococcus pneumoniae with recombinant penicillin-binding protein genes from a penicillin-resistant strain. J Infect Chemother. 2005 Apr;11(2):107-11. PubMed PMID: 15856382.
10: Kurazono M, Ida T, Yamada K, Hirai Y, Maruyama T, Shitara E, Yonezawa M. In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci. Antimicrob Agents Chemother. 2004 Aug;48(8):2831-7. PubMed PMID: 15273088; PubMed Central PMCID: PMC478537.
11: Bert F. [Risk factors and treatment of methicillin-resistant Staphylococcus aureus infections]. Presse Med. 2002 Nov 30;31(38):1792-6. Review. French. PubMed PMID: 12497719.
