WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524878
CAS#: 209331-43-1
Description: CP-8668 is an orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzindolone skeleton. CP8668 showed selective affinity for human progesterone receptor equal in strength to other steroidal progestins.
Hodoodo Cat#: H524878
Name: CP-8668
CAS#: 209331-43-1
Chemical Formula: C21H30N2O4
Exact Mass: 374.22
Molecular Weight: 374.470
Elemental Analysis: C, 67.35; H, 8.07; N, 7.48; O, 17.09
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Synonym: CP-8668; CP8668; CP 8668; UNII-5371O2R79D.
IUPAC/Chemical Name: Carbamic acid, N-propyl-, (4aR,5R,6R,7R)-2,4,4a,5,6,7-hexahydro-7-methoxy-1,3,4a,5-tetramethyl-2-oxo-1H-benz(f)indol-6-yl ester
InChi Key: HHRZNPFAGIHNGP-ZEZXVUOJSA-N
InChi Code: InChI=1S/C21H30N2O4/c1-7-8-22-20(25)27-18-13(3)21(4)11-15-12(2)19(24)23(5)16(15)9-14(21)10-17(18)26-6/h9-10,13,17-18H,7-8,11H2,1-6H3,(H,22,25)/t13-,17+,18+,21+/m0/s1
SMILES Code: CCCNC(=O)O[C@@H]1[C@@H]([C@]2(CC3=C(C(=O)N(C3=CC2=C[C@H]1OC)C)C)C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
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The following data is based on the product molecular weight 374.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kurihara K, Shinei R, Tanabe K, Tabata Y, Kurata Y, Hoshiko S, Okonogi T. Nonsteroidal progesterone receptor ligands (II); synthesis and SAR of new tetrahydrobenzindolone derivatives. Bioorg Med Chem. 2006 Jul 15;14(14):4862-78. Epub 2006 Mar 31. PubMed PMID: 16580209.
2: Tabata Y, Iizuka Y, Shinei R, Kurihara K, Okonogi T, Hoshiko S, Kurata Y. CP8668, a novel orally active nonsteroidal progesterone receptor modulator with tetrahydrobenzindolone skeleton. Eur J Pharmacol. 2003 Feb 7;461(1):73-8. Erratum in: Eur J Pharmacol. 2003 Apr 4;465(3):299. PubMed PMID: 12568918.