WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H208454
CAS#: 1187568-16-6
Description: JND003 is a new selective estrogen-related receptor α agonist alleviating nonalcoholic fatty liver disease and insulin resistance.
Hodoodo Cat#: H208454
Name: JND003
CAS#: 1187568-16-6
Chemical Formula: C16H14N2O2
Exact Mass: 266.11
Molecular Weight: 266.300
Elemental Analysis: C, 72.17; H, 5.30; N, 10.52; O, 12.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: JND-003
IUPAC/Chemical Name: 7-Methoxy-3-methyl-2-phenylquinazolin-4(3H)-one
InChi Key: CAPYSCGIBNZCLS-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14N2O2/c1-18-15(11-6-4-3-5-7-11)17-14-10-12(20-2)8-9-13(14)16(18)19/h3-10H,1-2H3
SMILES Code: O=C1N(C)C(C2=CC=CC=C2)=NC3=C1C=CC(OC)=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 266.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Mao L, Peng L, Ren X, Chu Y, Nie T, Lin W, Zhao X, Libby A, Xu Y, Chang Y, Lei C, Loomes K, Wang N, Liu J, Levi M, Wu D, Hui X, Ding K. Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance. ACS Bio Med Chem Au. 2022 Jun 15;2(3):282-296. doi: 10.1021/acsbiomedchemau.1c00050. Epub 2022 Jan 31. PMID: 35874496; PMCID: PMC9302452.
