WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H318470
CAS#: 6493-05-6
Description: Pentoxifylline is a drug used to treat muscle pain in people with peripheral artery disease. Like other methylated xanthine derivatives, pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. It is being investigated for treatment of Alzheimer's disease. It is generic and sold under many brand names worldwide.
Hodoodo Cat#: H318470
Name: Pentoxifylline
CAS#: 6493-05-6
Chemical Formula: C13H18N4O3
Exact Mass: 278.14
Molecular Weight: 278.310
Elemental Analysis: C, 56.10; H, 6.52; N, 20.13; O, 17.25
Synonym: Pentoxifylline, Dimethyloxohexylxanthine, EHT 0202, BL 191, Oxpentifylline, Pentoxifilina, Theobromine, Trental, Vazofirin, EHT0202, BL191, EHT-0202, BL-191; Etazolate
IUPAC/Chemical Name: 1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion
InChi Key: BYPFEZZEUUWMEJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3
SMILES Code: c12c(n(c(=O)n(c1=O)CCCCC(C)=O)C)ncn2C
Appearance: White to light yellow solid powder.
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 278.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Goksu E, Dogan O, Ulker P, Tanrıover G, Konuk E, Dilmac S, Kirac E, Demır N, Aslan M. Pentoxifylline Alleviates Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage. Acta Neurochir (Wien). 2016 Jun 16. [Epub ahead of print] PubMed PMID: 27311763.
2: Mancano MA. Gastrointestinal Nodules and Bleeding with Long-Term Lanthanum Use; DRESS and Hepatotoxicity Due to Rivaroxaban; Thrombocytopenia Induced by Pentoxifylline; Amlodipine-Induced Schamberg's Disease; Varenicline-Induced Acute Liver Injury. Hosp Pharm. 2016 Apr;51(4):284-7. doi: 10.1310/hpj5104-284. PubMed PMID: 27303074; PubMed Central PMCID: PMC4896329.
3: Rosendahl J. [Pentoxifylline in severe acute pancreatits - a promising approach?]. Z Gastroenterol. 2016 Jun;54(6):581-2. doi: 10.1055/s-0042-101566. Epub 2016 Jun 10. German. PubMed PMID: 27284935.
4: Karim MR, Ahmed H, Paul RK, Chowdhury M, Alam MS, Saha A. Comparative Study between Pentoxifylline and Pioglitazone in the Treatment of Non-Alcoholic Fatty Liver Disease among Newly Detected Glucose Intolerant Patients. Mymensingh Med J. 2016 Apr;25(2):198-204. PubMed PMID: 27277347.
5: Turner E. Pentoxifylline as adjunct therapy to long-term clinical management of a right-to-left patent ductus arteriosus. Can Vet J. 2016 Jun;57(6):655-6. PubMed PMID: 27247468; PubMed Central PMCID: PMC4866675.
6: Kim HK, Hwang SH, Lee SO, Kim SH, Abdi S. Pentoxifylline Ameliorates Mechanical Hyperalgesia in a Rat Model of Chemotherapy-Induced Neuropathic Pain. Pain Physician. 2016 May;19(4):E589-600. PubMed PMID: 27228525.
7: Vilar-Pereira G, Resende Pereira I, de Souza Ruivo LA, Cruz Moreira O, da Silva AA, Britto C, Lannes-Vieira J. Combination Chemotherapy with Suboptimal Doses of Benznidazole and Pentoxifylline Sustains Partial Reversion of Experimental Chagas' Heart Disease. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4297-309. doi: 10.1128/AAC.02123-15. Print 2016 Jul. PubMed PMID: 27161638.
8: Feyli SA, Ghanbari A, Keshtmand Z. Therapeutic effect of pentoxifylline on reproductive parameters in diabetic male mice. Andrologia. 2016 May 2. doi: 10.1111/and.12604. [Epub ahead of print] PubMed PMID: 27135184.
9: Mehrzad V, Afshar R, Akbari M. Pentoxifylline treatment in patients with cancer cachexia: A double-blind, randomized, placebo-controlled clinical trial. Adv Biomed Res. 2016 Mar 22;5:60. doi: 10.4103/2277-9175.179182. eCollection 2016. PubMed PMID: 27135029; PubMed Central PMCID: PMC4832883.
10: Cavalcanti AL, Reis MY, Silva GC, Ramalho ÍM, Guimarães GP, Silva JA, Saraiva KL, Damasceno BP. Microemulsion for topical application of pentoxifylline: In vitro release and in vivo evaluation. Int J Pharm. 2016 Jun 15;506(1-2):351-60. doi: 10.1016/j.ijpharm.2016.04.065. Epub 2016 Apr 27. PubMed PMID: 27130362.
11: Carson C, Al-Makki A, Shepler B. Can Pentoxifylline be used as Adjunct Therapy to ACE Inhibitors and ARBs in Preserving Kidney Function? J Pharm Pharm Sci. 2016 Jan-Mar;19(1):1-7. doi: 10.18433/J3K020. PubMed PMID: 27096690.
12: Minicucci M, Oliveira F, Santos P, Polegato B, Roscani M, Fernandes AA, Lustosa B, Paiva S, Zornoff L, Azevedo P. Pentoxifylline Attenuates Cardiac Remodeling Induced by Tobacco Smoke Exposure. Arq Bras Cardiol. 2016 May;106(5):396-403. doi: 10.5935/abc.20160057. Epub 2016 Apr 19. English, Portuguese. PubMed PMID: 27096523; PubMed Central PMCID: PMC4914004.
13: Gökalp O, Karakaş Yeşilkaya N, Beşir Y, Gürbüz A. Effects of pentoxifylline on blood transfusion. Anatol J Cardiol. 2016 Mar;16(3):226. doi: 10.14744/AnatolJCardiol.2016.6838. PubMed PMID: 27067574.
14: Cook M, Johnson N, Zegzula HD, Schray M, Glissmeyer M, Sorenson L. Prophylactic use of pentoxifylline (Trental) and vitamin E to prevent capsular contracture after implant reconstruction in patients requiring adjuvant radiation. Am J Surg. 2016 May;211(5):854-9. doi: 10.1016/j.amjsurg.2016.01.006. Epub 2016 Feb 22. PubMed PMID: 27016313.
15: Jafari-Sabet M, Shishegar A, Saeedi AR, Ghahari S. Pentoxifylline Increases Antiadhesion Effect of Streptokinase on Postoperative Adhesion Formation: Involvement of Fibrinolytic Pathway. Indian J Surg. 2015 Dec;77(Suppl 3):837-42. doi: 10.1007/s12262-013-1025-y. Epub 2014 Jan 14. PubMed PMID: 27011467; PubMed Central PMCID: PMC4775670.
16: Leporini C, Pisano A, Russo E, D'Arrigo G, de Sarro G, Coppolino G, Bolignano D. Effect of pentoxifylline on renal outcomes in chronic kidney disease patients: A systematic review and meta-analysis. Pharmacol Res. 2016 May;107:315-32. doi: 10.1016/j.phrs.2016.03.001. Epub 2016 Mar 17. Review. PubMed PMID: 26995301.
17: Al-Sudany NK. Treatment of primary perniosis with oral pentoxifylline (a double-blind placebo-controlled randomized therapeutic trial). Dermatol Ther. 2016 Mar 15. doi: 10.1111/dth.12350. [Epub ahead of print] PubMed PMID: 26991468.
18: Takhtfooladi HA, Hesaraki S, Razmara F, Takhtfooladi MA, Hajizadeh H. Effects of N-acetylcysteine and pentoxifylline on remote lung injury in a rat model of hind-limb ischemia/reperfusion injury. J Bras Pneumol. 2016 Feb;42(1):9-14. doi: 10.1590/S1806-37562016000000183. English, Portuguese. PubMed PMID: 26982035; PubMed Central PMCID: PMC4805381.
19: Patel V, Gadiwalla Y, Sassoon I, Sproat C, Kwok J, McGurk M. Prophylactic use of pentoxifylline and tocopherol in patients who require dental extractions after radiotherapy for cancer of the head and neck. Br J Oral Maxillofac Surg. 2016 Jun;54(5):547-50. doi: 10.1016/j.bjoms.2016.02.024. Epub 2016 Mar 11. PubMed PMID: 26975577.
20: Kelten B, Erdogan H, Antar V, Sanel S, Tuncdemir M, Kutnu M, Karaoglan A, Orki T. Pentoxifylline Inhibits Epidural Fibrosis in Post-Laminectomy Rats. Med Sci Monit. 2016 Mar 14;22:840-7. PubMed PMID: 26974057; PubMed Central PMCID: PMC4793638.
