WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525068
CAS#: 36740-73-5
Description: Flumizole is an anti-inflammatory agent. It is a non-steroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX).
Hodoodo Cat#: H525068
Name: Flumizole
CAS#: 36740-73-5
Chemical Formula: C18H15F3N2O2
Exact Mass: 348.11
Molecular Weight: 348.320
Elemental Analysis: C, 62.07; H, 4.34; F, 16.36; N, 8.04; O, 9.19
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Synonym: Flumizole; UNII-Y4YQF944N9; CP-22665; Flumizolum; Flumizol; Flumizole (USAN/INN); AC1L1XWB; Flumizol [INN-Spanish]; CP 22665. CP-22,665.
IUPAC/Chemical Name: 4,5-Bis(p-methoxyphenyl)-2-(trifluoromethyl)imidazole
InChi Key: OPYFPDBMMYUPME-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23)
SMILES Code: c1(c(c2ccc(OC)cc2)nc([nH]1)C(F)(F)F)c1ccc(OC)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 348.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bender PE, Hill DT, Offen PH, Razgaitis K, Lavanchy P, Stringer OD, Sutton BM, Griswold DE, DiMartino M, Walz DT, et al. 5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: a new class of immunoregulatory antiinflammatory agents. J Med Chem. 1985 Sep;28(9):1169-77. PubMed PMID: 4032421.
2: Szczeklik A. Antipyretic analgesics and the allergic patient. Am J Med. 1983 Nov 14;75(5A):82-4. PubMed PMID: 6606363.
3: Kangasaho M, Vapaatalo H. TXA2-antagonistic properties of agents affecting prostaglandin synthesis or the cyclic nucleotide system in human platelets. Acta Pharmacol Toxicol (Copenh). 1983 Aug;53(2):130-4. PubMed PMID: 6624480.
4: McIlhenny HM, Levine S, Wiseman EH, Sowinski R. Disposition and activity in experimental allergic encephalomyelitis of flumizole, a nonacidic, nonsteroidal, anti-inflammatory agent. Exp Neurol. 1978 Jan 1;58(1):126-37. PubMed PMID: 618737.
5: Wiseman EH, McIlhenny HM, Bettis JW. Flumizole, a new nonsteroidal anti-inflammatory agent. J Pharm Sci. 1975 Sep;64(9):1469-75. PubMed PMID: 810570.