WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H121038
CAS#: 1399849-02-5 (free base)
Description: SPH3127 is a Highly Potent, and Orally Active Direct Renin Inhibitor. SPH3127 demonstrated higher bioavailability and a more potent antihypertensive effect in preclinical models than aliskiren and has completed a phase II clinical trial for essential hypertension.
Hodoodo Cat#: H121038
Name: SPH3127
CAS#: 1399849-02-5 (free base)
Chemical Formula: C22H32N6O4
Exact Mass: 444.25
Molecular Weight: 444.540
Elemental Analysis: C, 59.44; H, 7.26; N, 18.91; O, 14.40
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Related CAS #: 2102663-60-3 (malate) 1399849-02-5 (free base)
Synonym: SPH3127; SPH 3127; SPH-3127; sitokiren; sitokirenum
IUPAC/Chemical Name: methyl (3-(3-((R)-1-((R)-N-cyclopropylmorpholine-2-carboxamido)ethyl)-6-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl)propyl)carbamate
InChi Key: GRTDDIZIUSADLD-CRAIPNDOSA-N
InChi Code: InChI=1S/C22H32N6O4/c1-14-5-8-17-19(26-27(20(17)25-14)11-4-9-24-22(30)31-3)15(2)28(16-6-7-16)21(29)18-13-23-10-12-32-18/h5,8,15-16,18,23H,4,6-7,9-13H2,1-3H3,(H,24,30)/t15-,18-/m1/s1
SMILES Code: COC(NCCCN1N=C([C@@H](C)N(C([C@H]2CNCCO2)=O)C3CC3)C4=C1N=C(C)C=C4)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 444.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Zhang L, Mao Y, Gao Z, Chen X, Li X, Liu Y, Xia G. The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor. Eur J Drug Metab Pharmacokinet. 2020 Feb;45(1):15-26. doi: 10.1007/s13318-019-00573-9. PMID: 31494843.