WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130447
CAS#: 2863670-67-9 (sodium)
Description: YCT529, an RAR-α inhibitor, is used as a contraceptive, with a 99% effectiveness. YCT529 acts as a potent and selective antagonist of the Vitamin A receptor retinoic acid receptor alpha (RAR-α). In studies on mice it produced a 99% reduction in sperm production, and it has proceeded to early stage human clinical trials as a potential male contraceptive.
Hodoodo Cat#: H130447
Name: YCT529
CAS#: 2863670-67-9 (sodium)
Chemical Formula: C29H24NNaO3
Exact Mass: 457.17
Molecular Weight: 457.500
Elemental Analysis: C, 76.13; H, 5.29; N, 3.06; Na, 5.03; O, 10.49
Related CAS #: 2863670-67-9 (sodium) 2863670-66-8 (free acid)
Synonym: YCT529; YCT 529; YCT-529
IUPAC/Chemical Name: sodium 4-(5-(2,2-dimethyl-4-(p-tolyl)-2H-chromen-6-yl)-1H-pyrrol-2-yl)benzoate
InChi Key: NNFWFHLHNJSJTH-UHFFFAOYSA-M
InChi Code: InChI=1S/C29H25NO3.Na/c1-18-4-6-19(7-5-18)24-17-29(2,3)33-27-15-12-22(16-23(24)27)26-14-13-25(30-26)20-8-10-21(11-9-20)28(31)32;/h4-17,30H,1-3H3,(H,31,32);/q;+1/p-1
SMILES Code: O=C([O-])C1=CC=C(C2=CC=C(C3=CC(C(C4=CC=C(C)C=C4)=CC(C)(C)O5)=C5C=C3)N2)C=C1.[Na+]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 457.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://www.acs.org/pressroom/newsreleases/2022/march/non-hormonal-pill-could-soon-expand-mens-birth-control-options.html
2. https://www.biorender.com/blog/the-new-male-contraceptive-pill-downloadable-infographic