WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130517
CAS#: 1851412-93-5 (free acid)
Description: TACH101 (formerly QC8222) is a selective pan-inhibitor of histone lysine demethylase 4 (KDM4). It was shown to block the proliferation of multiple cancer cell lines in patient-derived organoid models.
Hodoodo Cat#: H130517
Name: TACH101
CAS#: 1851412-93-5 (free acid)
Chemical Formula: C26H29N3O3
Exact Mass: 431.22
Molecular Weight: 431.536
Elemental Analysis: C, 72.37; H, 6.77; N, 9.74; O, 11.12
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Related CAS #: 1851412-93-5 (free acid) 2908753-08-0 (potassium) 2908753-07-9 (sodium)
Synonym: TACH 101, TACH-101, QC8222, QC 8222, QC-8222
IUPAC/Chemical Name: (S)-3-(((7-((4-Isopropylphenyl)(methyl)amino)chroman-4-yl)methyl)amino)isonicotinic acid
InChi Key: NDVITLLKZQXKGU-LJQANCHMSA-N
InChi Code: InChI=1S/C26H29N3O3/c1-17(2)18-4-6-20(7-5-18)29(3)21-8-9-22-19(11-13-32-25(22)14-21)15-28-24-16-27-12-10-23(24)26(30)31/h4-10,12,14,16-17,19,28H,11,13,15H2,1-3H3,(H,30,31)/t19-/m1/s1
SMILES Code: O=C(O)C1=CC=NC=C1NC[C@H]2CCOC3=C2C=CC(N(C4=CC=C(C(C)C)C=C4)C)=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 431.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Chandhasin C, Dang V, Perabo F, Del Rosario J, Chen YK, Filvaroff E, Stafford JA, Clarke M. TACH101, a first-in-class pan-inhibitor of KDM4 histone demethylase. Anticancer Drugs. 2023 Mar 24. doi: 10.1097/CAD.0000000000001514. Epub ahead of print. PMID: 37067993.