WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124492
CAS#: 1147090-70-7 (3H2O)
Description: CZ-48 is a DNA topoisomerase inhibitor potentially for the treatment of solid tumours and lymphoma. CZ-48 is an esterification product from the reaction of natural camptothecin with propionic anhydride.
Hodoodo Cat#: H124492
Name: CZ-48 trihydrate
CAS#: 1147090-70-7 (3H2O)
Chemical Formula: C23H26N2O8
Exact Mass: 458.17
Molecular Weight: 458.470
Elemental Analysis: C, 60.26; H, 5.72; N, 6.11; O, 27.92
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Related CAS #: 194414-69-2 (free base) 1147090-70-7 (3H2O)
Synonym: CZ-48 trihydrate; TR4HR67FMA; UNII-TR4HR67FMA; Camptothecin-20-o-propionate trihydrate; Camptothecin-20(S)-o-propionate trihydrate
IUPAC/Chemical Name: 4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl propionate trihydrate
InChi Key: IYMREUZGKUWKHF-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H20N2O5.3H2O/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28;;;/h5-10H,3-4,11-12H2,1-2H3;3*1H2
SMILES Code: CCC(=O)OC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)CC.O.O.O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 458.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Liu X, Cao Z, Mendoza J, Vardeman D, Giovanella B. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206. PubMed PMID: 24648919; PubMed Central PMCID: PMC3917724.
2: Liu X, Wang Y, Cao Z, Zhan M, Vardeman D, Giovanella B. Enhanced lactone stability of CZ48 in blood correlates to its lack of toxicity in mice. J Pharm Pharm Sci. 2013;16(1):115-24. PubMed PMID: 23683610.
3: Liu X, Dejesus A, Cao Z, Vardeman D, Giovanella B. Metabolic difference of CZ48 in human and mouse liver microsomes. Int J Mol Sci. 2012;13(5):5498-505. doi: 10.3390/ijms13055498. PubMed PMID: 22754310; PubMed Central PMCID: PMC3382816.
4: Liu X, Wang Y, Vardeman D, Cao Z, Giovanella B. Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):84-9. doi: 10.1016/j.jchromb.2008.03.013. PubMed PMID: 18396471.
5: Liehr JG, Harris NJ, Mendoza J, Ahmed AE, Giovanella BC. Pharmacology of camptothecin esters. Ann N Y Acad Sci. 2000;922:216-23. Review. PubMed PMID: 11193897.
6: Cao Z, Kozielski A, Liu X, Wang Y, Vardeman D, Giovanella B. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. doi: 10.1158/0008-5472.CAN-08-4452. PubMed PMID: 19458069.