WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124482
CAS#: 2141996-20-3 (mesylate)
Description: Vamotinib is a tyrosine kinase inhibitor and an antineoplastic. Vamotinib is a novel TKI developed with the specifications of (i) targeting T315I and other resistance mutations in BCR/ABL; (ii) achieving a high selectivity to improve safety; and (iii) overcoming nonmutational resistance in Ph+ leukemias. Vamotinib has potential with the treatment of resistant Ph+ leukemia.
Hodoodo Cat#: H124482
Name: Vamotinib mesylate
CAS#: 2141996-20-3 (mesylate)
Chemical Formula: C30H31F3N6O4S
Exact Mass: 628.21
Molecular Weight: 628.670
Elemental Analysis: C, 57.32; H, 4.97; F, 9.07; N, 13.37; O, 10.18; S, 5.10
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 2141996-20-3 (mesylate) 1416241-23-0 (free base)
Synonym: PF-114 mesilate; PF-114 mesylate; PF-114 methanesulfonate; 372ZE79K3S; 2141996-20-3; Vamotinib mesylate; UNII-372ZE79K3S;
IUPAC/Chemical Name: 3-([1,2,4]triazolo[4,3-a]pyridin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide methanesulfonate
InChi Key: CCNAIKOABJPEAN-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H27F3N6O.CH4O3S/c1-20-6-7-22(17-21(20)9-11-27-35-34-26-5-3-4-12-38(26)27)28(39)33-24-10-8-23(25(18-24)29(30,31)32)19-37-15-13-36(2)14-16-37;1-5(2,3)4/h3-8,10,12,17-18H,13-16,19H2,1-2H3,(H,33,39);1H3,(H,2,3,4)
SMILES Code: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=NN=C5N4C=CC=C5.CS(=O)(=O)O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 628.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |