WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124746
CAS#: 41992-23-8 (free base)
Description: Spirogermanium is a germanium derivative.
Hodoodo Cat#: H124746
Name: Spirogermanium
CAS#: 41992-23-8 (free base)
Chemical Formula: C17H36GeN2
Exact Mass: 342.21
Molecular Weight: 341.120
Elemental Analysis: C, 59.86; H, 10.64; Ge, 21.29; N, 8.21
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Related CAS #: 41992-23-8 (free base) 41992-22-7 (HCl)
Synonym: PIROGERMANIUM; Spirogermanio; 41992-23-8; Spirogermanium;
IUPAC/Chemical Name: 3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-N,N-dimethylpropan-1-amine
InChi Key: PWMYMKOUNYTVQN-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H36GeN2/c1-5-18(6-2)11-8-17(9-12-18)10-15-20(16-17)14-7-13-19(3)4/h5-16H2,1-4H3
SMILES Code: CN(C)CCCN1CC2(CC[Ge](CC)(CC)CC2)CC1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 341.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Slavik M, Blanc O, Davis J. Spirogermanium: a new investigational drug of
novel structure and lack of bone marrow toxicity. Invest New Drugs.
1983;1(3):225-34. doi: 10.1007/BF00208894. PMID: 6678870.
2: DiMartino MJ, Lee JC, Badger AM, Muirhead KA, Mirabelli CK, Hanna N.
Antiarthritic and immunoregulatory activity of spirogermanium. J Pharmacol Exp
Ther. 1986 Jan;236(1):103-10. PMID: 2934544.
3: Schwartz GN, Biegel JA, Fisher B, Klein I. Spirogermanium: effects on
hematopoietic stem cells and survival of normal and tumor-bearing mice. Proc Soc
Exp Biol Med. 1983 Jun;173(2):176-80. doi: 10.3181/00379727-173-41627. PMID:
6866997.
4: Hill BT, Whelan RD. Spirogermanium--a novel antitumour agent expressing a
lack of cross-resistance in vitro with a range of 'standard' antitumour drugs.
Invest New Drugs. 1986;4(4):359-65. doi: 10.1007/BF00173508. PMID: 3583643.
5: Mirabelli CK, Badger AM, Sung CP, Hillegass L, Sung CM, Johnson RK, Picker D,
Schwartz D, Dorman J, Martellucci S. Pharmacological activities of
spirogermanium and other structurally related azaspiranes: effects on tumor cell
and macrophage functions. Anticancer Drug Des. 1989 Mar;3(4):231-42. PMID:
2930625.
6: Mrema JE, Slavik M, Davis J. Spirogermanium: a new drug with antimalarial
activity against chloroquine-resistant Plasmodium falciparum. Int J Clin
Pharmacol Ther Toxicol. 1983 Apr;21(4):167-71. PMID: 6345410.
