WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124806
CAS#: Donafenib mesylate
Description: Donafenib is an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases with potential anticancer acivity. Donafenib is under clinical trials in China in patients with advanced hepatocellular carcinoma (HCC).
Hodoodo Cat#: H124806
Name: Donafenib mesylate
CAS#: Donafenib mesylate
Chemical Formula: C22H20ClF3N4O6S
Exact Mass: 560.07
Molecular Weight: 560.930
Elemental Analysis: C, 47.11; H, 3.59; Cl, 6.32; F, 10.16; N, 9.99; O, 17.11; S, 5.72
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Related CAS #: 1130115-44-4 (free base) Donafenib mesylate
Synonym: DONAFENIB MESILATE; DONAFENIB MESYLATE; F3C1QUT2IS; CM-4307 MESYLATE;
IUPAC/Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide methanesulfonate
InChi Key: IYEOGVPDPILUDO-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H16ClF3N4O3.CH4O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-5(2,3)4/h2-11H,1H3,(H,26,30)(H2,28,29,31);1H3,(H,2,3,4)
SMILES Code: CNC(C1=NC=CC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2)=C1)=O.CS(=O)(O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 560.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
