WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124809
CAS#: 343935-60-4 (free base)
Description: Sulcardine is a multi-ion channel blocker potentially for the treatment of arrhythmia.
Hodoodo Cat#: H124809
Name: Sulcardine
CAS#: 343935-60-4 (free base)
Chemical Formula: C24H33N3O4S
Exact Mass: 459.22
Molecular Weight: 459.610
Elemental Analysis: C, 62.72; H, 7.24; N, 9.14; O, 13.92; S, 6.98
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Related CAS #: 343935-60-4 (free base) 343935-61-5 (sulfate) 934843-86-4 (sulfate trihydrate)
Synonym: Sulcardine; UNII-4Q5HLV8HG1; 4Q5HLV8HG1; 343935-60-4
IUPAC/Chemical Name: N-(4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)benzyl)-4-methoxybenzenesulfonamide
InChi Key: SYZGIWXQGIBJGN-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H33N3O4S/c1-31-22-6-8-23(9-7-22)32(29,30)25-16-19-14-20(17-26-10-2-3-11-26)24(28)21(15-19)18-27-12-4-5-13-27/h6-9,14-15,25,28H,2-5,10-13,16-18H2,1H3
SMILES Code: COC1=CC=C(C=C1)S(=O)(=O)NCC2=CC(=C(C(=C2)CN3CCCC3)O)CN4CCCC4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 459.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wang W, Qian HJ, Xin L, Zhang MQ, Lu DY, Jin JM, Liu GY, Jia JY, Zheng HC, Yu C, Wang YP, Zhu F, Liu Y. Multiple Dose Pharmacokinetics and Safety of Sulcardine Sulfate in Healthy Chinese Male Subjects: An Open-Label Phase I Clinical Study. Eur J Drug Metab Pharmacokinet. 2016 Aug 22. [Epub ahead of print] PubMed PMID: 27550655.
2: Jia J, Liu G, Zhang M, Lu Y, Lu C, Liu Y, Zheng H, Wang W, Gui Y, Yu C, Li S, Wang Y. Determination of the novel antiarrhythmic drug sulcardine sulfate in human plasma by liquid chromatography tandem mass spectrometry and its application in a clinical pharmacokinetic study. Biomed Chromatogr. 2016 Aug;30(8):1291-6. doi: 10.1002/bmc.3681. PubMed PMID: 26715470.
3: Chen Q, Qian HJ, Wang W, Zhang MQ, Lu DY, Lu C, Jin JM, Hu CY, Liu GY, Jia JY, Zheng HC, Li XN, Yu C, Wang YP, Liu Y. Pharmacokinetics, safety, and tolerability of sulcardine sulfate: an open-label, single-dose, randomized study in healthy Chinese subjects. Fundam Clin Pharmacol. 2017 Feb;31(1):120-125. doi: 10.1111/fcp.12242. PubMed PMID: 27599871.
4: Lu YL, Li SJ, Liu GY, Li XC, Yang D, Jia JY, Zhang MQ, Zheng HC, Yu C, Zhu F, Wang YP. Oral Bioavailability and Mass Balance Studies of a Novel Anti-arrhythmic Agent Sulcardine Sulfate in Sprague-Dawley Rats and Beagle Dogs. Eur J Drug Metab Pharmacokinet. 2016 Jul 11. [Epub ahead of print] PubMed PMID: 27402487.
5: Lee JY, Lucchesi BR. HBI-3000 prevents secondary sudden cardiac death. J Cardiovasc Pharmacol Ther. 2013 Sep;18(5):453-9. doi: 10.1177/1074248413485433. PubMed PMID: 23615576.
6: Bai DL, Chen WZ, Bo YX, Dong YL, Kang AL, Sun WK, Wang W, Hu ZL, Wang YP. Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012 Sep;33(9):1176-86. doi: 10.1038/aps.2012.119. PubMed PMID: 22922342; PubMed Central PMCID: PMC4003109.
7: Guo D, Liu Q, Liu T, Elliott G, Gingras M, Kowey PR, Yan GX. Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85. doi: 10.1097/FJC.0b013e3181ffe8b3. PubMed PMID: 20980921.