JNJ-40929837 succinate

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Hodoodo CAT#: H124829

CAS#: 1191044-47-9 (succinate)

Description: JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.

Chemical Structure

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JNJ-40929837 succinate
CAS# 1191044-47-9 (succinate)
Instruction

Theoretical Analysis

Hodoodo Cat#: H124829
Name: JNJ-40929837 succinate
CAS#: 1191044-47-9 (succinate)
Chemical Formula: C26H30N4O6S
Exact Mass: 526.19
Molecular Weight: 526.610
Elemental Analysis: C, 59.30; H, 5.74; N, 10.64; O, 18.23; S, 6.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1191044-47-9 (succinate)   1191044-42-4 (free base)  

Synonym: JNJ-40929837 succinate; J43PP874SF; UNII-J43PP874SF; 1191044-47-9; SCHEMBL1888476

IUPAC/Chemical Name: N-(8-(4-(thiazolo[4,5-b]pyridin-2-yloxy)benzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide succinate

InChi Key: ASCCNTPYAKLKGG-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N4O2S.C4H6O4/c1-14(27)24-16-11-17-6-7-18(12-16)26(17)13-15-4-8-19(9-5-15)28-22-25-21-20(29-22)3-2-10-23-21;5-3(6)1-2-4(7)8/h2-5,8-10,16-18H,6-7,11-13H2,1H3,(H,24,27);1-2H2,(H,5,6)(H,7,8)

SMILES Code: CC(=O)NC1CC2CCC(C1)N2CC3=CC=C(C=C3)OC4=NC5=C(S4)C=CC=N5.C(CC(=O)O)C(=O)O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 526.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Barchuk W, Lambert J, Fuhr R, Jiang JZ, Bertelsen K, Fourie A, Liu X, Silkoff PE, Barnathan ES, Thurmond R. Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma. Pulm Pharmacol Ther. 2014 Oct;29(1):15-23. doi: 10.1016/j.pupt.2014.06.003. Epub 2014 Jul 10. PMID: 25018015.

2: Ward PD, La D. Testicular distribution and toxicity of a novel LTA4H inhibitor in rats. Toxicol Appl Pharmacol. 2014 Jul 1;278(1):26-30. doi: 10.1016/j.taap.2014.04.012. Epub 2014 Apr 22. PMID: 24769091.