WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124884
CAS#: CB-103 HCl
Description: CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors.
Hodoodo Cat#: H124884
Name: CB-103 HCl
CAS#: CB-103 HCl
Chemical Formula: C15H19ClN2O
Exact Mass: 278.12
Molecular Weight: 278.780
Elemental Analysis: C, 64.63; H, 6.87; Cl, 12.72; N, 10.05; O, 5.74
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Related CAS #: CB-103 HCl 218457-67-1 (free base)
Synonym: CB-103 HCl; CB-103 Hydrochloride; CB-103 HYDROCHLORIDE; 6-(4-(tert-butyl)phenoxy)pyridin-3-amine hydrochloride
IUPAC/Chemical Name: 6-(4-(tert-butyl)phenoxy)pyridin-3-amine hydrochloride
InChi Key: WLUQNBKZPMQGJG-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H18N2O.ClH/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14;/h4-10H,16H2,1-3H3;1H
SMILES Code: NC1=CC=C(OC2=CC=C(C(C)(C)C)C=C2)N=C1.[H]Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 278.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fabbro D, Bauer M, Murone M, Lehal R. Notch Inhibition in Cancer: Challenges and Opportunities. Chimia (Aarau). 2020 Oct 28;74(10):779-783. doi: 10.2533/chimia.2020.779. PMID: 33115560.
2: Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, González-Gaitán M, Arsenijevic Y, Zoete V, Aster JC, Bourquin JP, Radtke F. Pharmacological disruption of the Notch transcription factor complex. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16292-16301. doi: 10.1073/pnas.1922606117. Epub 2020 Jun 29. PMID: 32601208; PMCID: PMC7368267.
