WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124895
CAS#: 2204245-47-4 (potassium)
Description: Bamocaftor, also known as VX 659, is a CFTR channel (DeltaF508-CFTR Mutant) corrector in patients with Cystic Fibrosis who are homozygous for the F508del mutation of the CF transmembrane conductance regulator (CFTR) gene, or who are heterozygous for the F508del mutation and a minimal function (MF) CFTR mutation not likely to respond to tezacaftor, ivacaftor, or tezacaftor/ivacaftor and also in combination with tezacaftor and VX-561 in F508del/MF in patients with cystic fibrosis.
Hodoodo Cat#: H124895
Name: Bamocaftor potassium
CAS#: 2204245-47-4 (potassium)
Chemical Formula: C28H31F3KN5O4S
Exact Mass: 629.17
Molecular Weight: 629.740
Elemental Analysis: C, 53.40; H, 4.96; F, 9.05; K, 6.21; N, 11.12; O, 10.16; S, 5.09
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 2204245-47-4 (potassium) 2204245-48-5 (free base)
Synonym: Bamocaftor potassium; VX-659 potassium; VX-659 potassium salt; VY7D8MTV72; Bamocaftor potassium [USAN]
IUPAC/Chemical Name: potassium (S)-(phenylsulfonyl)(6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinoyl)amide
InChi Key: BWMSVLSYIQHCQP-FYZYNONXSA-M
InChi Code: InChI=1S/C28H32F3N5O4S.K/c1-19-17-26(2,3)35(18-19)24-21(25(37)34-41(38,39)20-7-5-4-6-8-20)9-10-22(32-24)36-15-11-23(33-36)40-16-14-27(12-13-27)28(29,30)31;/h4-11,15,19H,12-14,16-18H2,1-3H3,(H,34,37);/q;+1/p-1/t19-;/m0./s1
SMILES Code: [K+].C[C@@H]1CN(C2=C(C=CC(=N2)N3C=CC(OCCC4(CC4)C(F)(F)F)=N3)C(=O)[N-]S(=O)(=O)C5=CC=CC=C5)C(C)(C)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
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The following data is based on the product molecular weight 629.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
