WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124957
CAS#: 923262-96-8 (HCl)
Description: SAR407899 is a potent and selective Rho kinase inhibitor with promising antihypertensive activity. SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. SAR407899 is approximately 8-fold more active than fasudil. SAR407899 potently (mean IC(50) values: 122 to 280 nM) and species-independently relaxed precontracted isolated arteries of different species and different vascular beds. The antihypertensive effect of SAR407899 was superior to that of fasudil and Y-27632.
Hodoodo Cat#: H124957
Name: SAR407899 HCl
CAS#: 923262-96-8 (HCl)
Chemical Formula: C14H17ClN2O2
Exact Mass: 280.10
Molecular Weight: 280.750
Elemental Analysis: C, 59.89; H, 6.10; Cl, 12.63; N, 9.98; O, 11.40
Related CAS #: 923262-96-8 (HCl) 923359-38-0 (free base)
Synonym: 923262-96-8; 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride; SAR407899 hydrochloride; SAR-407899 hydrochloride; SAR407899 (hydrochloride)
IUPAC/Chemical Name: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride
InChi Key: KMNVOGVCCZNVNU-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H16N2O2.ClH/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11;/h1-3,8-9,11,15H,4-7H2,(H,16,17);1H
SMILES Code: Cl.O=C1NC=CC2=CC(OC3CCNCC3)=CC=C12
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 280.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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