WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H328506
CAS#: 54533-85-6
Description: Nizofenone, also known as Ekonal and Y-9179, is a thromboxane A2 (TXA2) biosynthesis inhibitor used as a neuroprotective drug and used to treat stroke.
Hodoodo Cat#: H328506
Name: Nizofenone
CAS#: 54533-85-6
Chemical Formula: C21H21ClN4O3
Exact Mass: 412.13
Molecular Weight: 412.874
Elemental Analysis: C, 61.09; H, 5.13; Cl, 8.59; N, 13.57; O, 11.63
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 54533-86-7 (fumarate salt) 54533-85-6 (free),
Synonym: Nizofenone; Y-9179; Y 9179; Y9179; Ekonal
IUPAC/Chemical Name: (2-chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imidazol-1-yl)-5-nitrophenyl)methanone
InChi Key: WZGBZLHGOVJDET-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21ClN4O3/c1-3-24(4-2)14-20-23-11-12-25(20)19-10-9-15(26(28)29)13-17(19)21(27)16-7-5-6-8-18(16)22/h5-13H,3-4,14H2,1-2H3
SMILES Code: O=C(C1=CC=CC=C1Cl)C2=CC([N+]([O-])=O)=CC=C2N3C=CN=C3CN(CC)CC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 412.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Liu Y, Zhuang X, Gou L, Ling X, Tian X, Liu L, Zheng Y, Zhang L, Yin X. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80. doi: 10.1016/j.pbb.2012.09.009. Epub 2012 Sep 28. PubMed PMID: 23026061.
2: Nakamura T, Tsumagari T. [Effects of nizofenone on experimental arrhythmia in dogs]. Nihon Yakurigaku Zasshi. 1984 Nov;84(5):441-51. Japanese. PubMed PMID: 6097519.
3: Miura Y, Inui J, Nakamura T. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. Nihon Yakurigaku Zasshi. 1985 Mar;85(3):159-65. Japanese. PubMed PMID: 4007706.
4: Saito I, Asano T, Ochiai C, Takakura K, Tamura A, Sano K. A double-blind clinical evaluation of the effect of Nizofenone (Y-9179) on delayed ischemic neurological deficits following aneurysmal rupture. Neurol Res. 1983;5(4):29-47. PubMed PMID: 6149485.
5: Yasuda H, Izumi N, Nakanishi M, Maruyama Y. Brain protection against oxygen deficiency by nizofenone. Adv Exp Med Biol. 1988;222:403-10. PubMed PMID: 3364265.
6: Kotake H, Nawada T, Matsumoto T, Kitamura H, Kaneda T, Hasegawa J, Mashiba H. Chronotropic effect of nizofenone fumarate in rabbit sino-atrial node in vitro. Br J Pharmacol. 1988 Dec;95(4):1175-80. PubMed PMID: 3219485; PubMed Central PMCID: PMC1854257.
7: Ohta T, Kikuchi H, Hashi K, Kudo Y. Nizofenone administration in the acute stage following subarachnoid hemorrhage. Results of a multi-center controlled double-blind clinical study. J Neurosurg. 1986 Mar;64(3):420-6. PubMed PMID: 3512795.
8: Mizoi K, Olca M, Fujimoto S, Abiko H, Suzuki J. [An experimental study on the protective effect of nizofenone in cerebral ischemia]. No To Shinkei. 1984 Nov;36(11):1089-93. Japanese. PubMed PMID: 6525322.
9: Yasuda H, Nakajima A. Brain protection against ischemic injury by nizofenone. Cerebrovasc Brain Metab Rev. 1993 Winter;5(4):264-76. Review. PubMed PMID: 8110594.
10: Morimoto Y, Fukuda T, Tsumagari T. [Effects of nizofenone on ischemic cerebral edema in Mongolian gerbils]. No To Shinkei. 1984 Oct;36(10):983-8. Japanese. PubMed PMID: 6518129.
