Levobetaxolol Hydrochloride
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Hodoodo CAT#: H328706

CAS#: 116209-55-3 (HCl)

Description: Levobetaxolol hydrochloride, also known as Betaxon and AL-1577A, is a cardioselective β-adrenergic receptor inhibitor that has been demonstrated to reduce intraocular pressure in patients affected with primary open-angle glaucoma and ocular hypertension.

Chemical Structure

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Levobetaxolol Hydrochloride
CAS# 116209-55-3 (HCl)
Instruction

Theoretical Analysis

Hodoodo Cat#: H328706
Name: Levobetaxolol Hydrochloride
CAS#: 116209-55-3 (HCl)
Chemical Formula: C18H30ClNO3
Exact Mass: 0.00
Molecular Weight: 343.892
Elemental Analysis: C, 62.87; H, 8.79; Cl, 10.31; N, 4.07; O, 13.96

Price and Availability

Size Price Availability Quantity
50mg USD 285 2 Weeks
100mg USD 500 2 Weeks
250mg USD 850 2 Weeks
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Related CAS #: 116209-55-3 (HCl)   93221-48-8 (free base)  

Synonym: Levobetaxolol hydrochloride; AL-1577A; AL 1577A; AL1577A; Betaxon;

IUPAC/Chemical Name: (S)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)propan-2-ol hydrochloride

InChi Key: CHDPSNLJFOQTRK-LMOVPXPDSA-N

InChi Code: InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H/t17-;/m0./s1

SMILES Code: O[C@@H](CNC(C)C)COC1=CC=C(CCOCC2CC2)C=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 343.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Quaranta L, Turano R, Pizzolante T. Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension. Clin Ophthalmol. 2007 Jun;1(2):93-7. PubMed PMID: 19668496; PubMed Central PMCID: PMC2704505.

2: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Nov;29(9):625-55. PubMed PMID: 18193114.

3: Lele BS, Hoffman AS. Insoluble ionic complexes of polyacrylic acid with a cationic drug for use as a mucoadhesive, ophthalmic drug delivery system. J Biomater Sci Polym Ed. 2000;11(12):1319-31. PubMed PMID: 11261874.