WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530217
CAS#: 247046-64-6 (citrate)
Description: Dilopetine Citrate is a tachykinin receptor modulator and a neurokinin receptor modulator potentially for the treatment of depression.
Hodoodo Cat#: H530217
Name: Dilopetine Citrate
CAS#: 247046-64-6 (citrate)
Chemical Formula: C19H27N3O8S
Exact Mass: 457.15
Molecular Weight: 457.498
Elemental Analysis: C, 49.88; H, 5.95; N, 9.18; O, 27.98; S, 7.01
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Related CAS #: 247046-52-2 (free base) 247046-64-6 (citrate)
Synonym: E-6006 Citrate; E-6039; E 6039; E6039; Dilopetine Citrate.
IUPAC/Chemical Name: (N,N-Dimethyl-N-[2-[1-(1-methyl-1H-pyrazol-5-yl)-1-(2-thienyl)methoxy]ethyl]amine citrate )
InChi Key: KRFGVGXHTYATEZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H19N3OS.C6H8O7/c1-15(2)8-9-17-13(12-5-4-10-18-12)11-6-7-14-16(11)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-7,10,13H,8-9H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES Code: CN1N=CC=C1C(C2=CC=CS2)OCCN(C)C.OC(C(O)=O)(CC(O)=O)CC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Related CAS# 247046-62-4 (Dilopetine free base) 247046-64-6 (Dilopetine citrate)
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 457.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhimin O, Haibing Z, Lan T, Wei Z, Gensheng Y. Asymmetric synthesis of duloxetine intermediate (S)-(-)-3-N-methylamino-1-(2-thienyl)-1-propanol using immobilized Saccharomyces cerevisiae in liquid-core sodium alginate/chitosan/sodium alginate microcapsules. Bioprocess Biosyst Eng. 2014 Nov;37(11):2243-50. doi: 10.1007/s00449-014-1202-9. PubMed PMID: 24798376.
2: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Mar;28(2):121-42. PubMed PMID: 16636723.
3: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Dec;26(10):801-27. PubMed PMID: 15672123.
4: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 Oct;24(8):525-51. PubMed PMID: 12500432.