WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H329501
CAS#: 942123-43-5 (soproxil)
Description: Inarigivir soproxil, also known as SB 9200, is an antiviral agent. SB 9200 is also a novel agonist of innate immunity, which shows potent antiviral activity against resistant HCV variants. SB 9200 has broad-spectrum antiviral activity against RNA viruses including hepatitis C virus (HCV), norovirus, respiratory syncytial virus, and influenza and has demonstrated activity against hepatitis B virus (HBV) in vitro and in vivo. In phase I clinical trials in chronically infected HCV patients, SB 9200 has been shown to reduce HCV RNA by up to 1.9 log10 .
Hodoodo Cat#: H329501
Name: Inarigivir soproxil
CAS#: 942123-43-5 (soproxil)
Chemical Formula: C26H38N7O12PS
Exact Mass: 703.20
Molecular Weight: 703.661
Elemental Analysis: C, 44.38; H, 5.44; N, 13.93; O, 27.28; P, 4.40; S, 4.56
Related CAS #: 942123-43-5 (soproxil) 475650-36-3 (free) 2172788-92-8 (ammonium)
Synonym: Inarigivir soproxil; SB 44 (dinucleotide); SB 9200; SB-9200; SB9200.
IUPAC/Chemical Name: (((((2S,3S,5S)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(((2R,3R,4R,5R)-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-ethyl-4-methoxytetrahydrofuran-3-yl)oxy)phosphoryl)thio)methyl isopropyl carbonate
InChi Key: VMDKICCZWKJSHV-OLTNJDQQSA-N
InChi Code: InChI=1S/C26H38N7O12PS/c1-5-15-20(21(39-4)24(44-15)32-7-6-17(35)31-25(32)36)45-46(38,47-12-40-26(37)42-13(2)3)41-9-16-14(34)8-18(43-16)33-11-30-19-22(27)28-10-29-23(19)33/h10-11,13-16,18,20-21,24,34H,5-9,12H2,1-4H3,(H2,27,28,29)(H,31,35,36)/t14-,15+,16-,18-,20+,21+,24+,46?/m0/s1
SMILES Code: O[C@@H](C[C@@H](N1C2=C(C(N)=NC=N2)N=C1)O3)[C@@H]3COP(O[C@@H]4[C@@H](CC)O[C@@H](N5CCC(NC5=O)=O)[C@@H]4OC)(SCOC(OC(C)C)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 703.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Dawood A, Abdul Basit S, Jayaraj M, Gish RG. Drugs in Development for
Hepatitis B. Drugs. 2017 Aug;77(12):1263-1280. doi: 10.1007/s40265-017-0769-2.
Review. PubMed PMID: 28660478; PubMed Central PMCID: PMC5529495.
2: Jones M, Cunningham ME, Wing P, DeSilva S, Challa R, Sheri A, Padmanabhan S,
Iyer RP, Korba BE, Afdhal N, Foster GR. SB 9200, a novel agonist of innate
immunity, shows potent antiviral activity against resistant HCV variants. J Med
Virol. 2017 Sep;89(9):1620-1628. doi: 10.1002/jmv.24809. Epub 2017 May 23. PubMed
PMID: 28303593; PubMed Central PMCID: PMC5513743.
3: Suresh M, Korolowicz KE, Balarezo M, Iyer RP, Padmanabhan S, Cleary D, Gimi R,
Sheri A, Yon C, Kallakury BV, Tucker RD, Afdhal N, Menne S. Antiviral Efficacy
and Host Immune Response Induction during Sequential Treatment with SB 9200
Followed by Entecavir in Woodchucks. PLoS One. 2017 Jan 5;12(1):e0169631. doi:
10.1371/journal.pone.0169631. eCollection 2017. PubMed PMID: 28056062; PubMed
Central PMCID: PMC5215947.
4: Korolowicz KE, Iyer RP, Czerwinski S, Suresh M, Yang J, Padmanabhan S, Sheri
A, Pandey RK, Skell J, Marquis JK, Kallakury BV, Tucker RD, Menne S. Antiviral
Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the
Woodchuck Model of Chronic Hepatitis B. PLoS One. 2016 Aug 23;11(8):e0161313.
doi: 10.1371/journal.pone.0161313. eCollection 2016. PubMed PMID: 27552102;
PubMed Central PMCID: PMC4995001.
