WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526534
CAS#: 47453-14-5
Description: UK-9040 is a gastric secretory inhibitor.
Hodoodo Cat#: H526534
Name: UK-9040
CAS#: 47453-14-5
Chemical Formula: C23H31NS
Exact Mass: 353.22
Molecular Weight: 353.568
Elemental Analysis: C, 78.13; H, 8.84; N, 3.96; S, 9.07
This product is not in stock, which may be available by custom synthesis.
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Synonym: UK-9040, UK 9040, UK9040
IUPAC/Chemical Name: Pyrrolidine, 1-(4-(5-(2,2-dimethylpropyl)-2-thienyl)-4-phenyl-3-butenyl)-, (Z)-
InChi Key: HZZXGWBOCXDVLV-MTJSOVHGSA-N
InChi Code: InChI=1S/C23H31NS/c1-23(2,3)18-20-13-14-22(25-20)21(19-10-5-4-6-11-19)12-9-17-24-15-7-8-16-24/h4-6,10-14H,7-9,15-18H2,1-3H3/b21-12-
SMILES Code: CC(C)(C)CC1=CC=C(/C(C2=CC=CC=C2)=C\CCN3CCCC3)S1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 353.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Hamer DB, Price AB, Baron JH. Morphological and pharmacological studies of the parietal cells of the stomach in the dog during periods of maximal acid output and after the gastric secretory inhibitor UK-9040. Gut. 1977 Feb;18(2):91-8. PubMed PMID: 852749; PubMed Central PMCID: PMC1411295.
2: Joffe SN, Polak JM, Pallone F, Bloom SR, Gaskin RJ, Barros D'sa AA, Baron JH. Gastrin, antral g cells, and gastric acid in secretagogue-induced and antihistamine-inhibited duodenal ulcers. Scand J Gastroenterol. 1977;12(1):27-32. PubMed PMID: 13481.
3: Joffe SN, Gaskin RJ, D'Sa AA. Prevention of secretagogue-induced ulcers in the rat. Gastroenterology. 1976 May;70(5 PT.1):751-2. PubMed PMID: 1261768.
4: Joffe SN, Gaskin R, Barros D'sa AA, Melo AA, Gribble JN, Girvan DP, Baron JH. Proceedings: Secretagogue-produced duodenal ulcers in the rat and their prevention by the gastric secretory inhibitor UK 9040. Br J Surg. 1975 Feb;62(2):157. PubMed PMID: 234768.
5: Hamer DB, Price AB, Baron JH. Proceedings: A morphological and pharmacological study of the parietal cells of the stomach in the dog during periods of maximal acid output and after the gastric secretory inhibitor UK-9040. Gut. 1974 Apr;15(4):336-7. PubMed PMID: 4151863.
6: Hamer DB, Baron JH, Spencer J. Studies with a new gastric secretory inhibitor (UK 9040) in the dog. Br J Surg. 1972 Nov;59(11):902. PubMed PMID: 4637105.