WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529522
CAS#: 2035046-17-2
Description: DG026 is a IRAP inhibitor. IRAP has been targeted with inhibitors that act as cognitive enhancers by reducing brain oxytocin degradation and enhance spine density in primary hippocampal neuron cultures. DG026 was also shown to be able to selectively downregulate IRAP-dependent cross-presentation by dendritic cells but leave ERAP1-dependent cross-presentation unaffected.
Hodoodo Cat#: H529522
Name: DG026
CAS#: 2035046-17-2
Chemical Formula: C35H40N3O4P
Exact Mass: 597.28
Molecular Weight: 597.696
Elemental Analysis: C, 70.33; H, 6.75; N, 7.03; O, 10.71; P, 5.18
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Related CAS #: 2035046-17-2 2007955-25-9
Synonym: DG026; DG-026; DG 026.
IUPAC/Chemical Name: (2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-4,4-diphenylbutyl)((R)-1-amino-3-phenylpropyl)phosphinic acid
InChi Key: FDAGDZVCWKCEEX-ITBZIINNSA-N
InChi Code: InChI=1S/C35H40N3O4P/c36-33(22-21-26-13-5-1-6-14-26)43(41,42)25-30(35(40)38-32(34(37)39)23-27-15-7-2-8-16-27)24-31(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30-33H,21-25,36H2,(H2,37,39)(H,38,40)(H,41,42)/t30?,32-,33+/m0/s1
SMILES Code: N[C@@H](CCC1=CC=CC=C1)P(CC(CC(C2=CC=CC=C2)C3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N)=O)=O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Insulin-regulated aminopeptidase (IRAP, also known as leucylcystinyl aminopeptidase, placental leucine aminopeptidase, and oxytocinase, EC 3.4.11.3) is a transmembrane zinc aminopeptidase that is tasked with several biological functions including the generation of antigenic peptides for crosspresentation, regulation of trafficking of glucose transporter type 4, control of oxytocin levels in pregnancy, and regulation of brain oxytocin and vasopressin levels.
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The following data is based on the product molecular weight 597.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity
Anastasia Mpakali, Emmanuel Saridakis, Karl Harlos, Yuguang Zhao, Paraskevi Kokkala, Dimitris Georgiadis, Petros Giastas, Athanasios Papakyriakou, and Efstratios Stratikos
Publication Date (Web): March 22, 2017 (Article)
DOI: 10.1021/acs.jmedchem.6b01890
