WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H529107
CAS#: 1446418-48-9 (hydroxyacetate)
Description: Prurisol, also known as abacavir hydroxyacetate and KM-133, is potentially for the treatment of plaque psoriasis
Hodoodo Cat#: H529107
Name: Abacavir hydroxyacetate
CAS#: 1446418-48-9 (hydroxyacetate)
Chemical Formula: C16H20N6O3
Exact Mass: 344.16
Molecular Weight: 344.370
Elemental Analysis: C, 55.80; H, 5.85; N, 24.40; O, 13.94
Related CAS #: 136470-78-5 (free base) 136777-48-5 (HCl) 168146-84-7 (succinate) 188062-50-2 (sulfate) 1446418-48-9 (hydroxyacetate) 384380-52-3 (carboxylate)
Synonym: KM-133; KM133; KM 133; Prurisol; Abacavir acetate; Abacavir hydroxyacetate;
IUPAC/Chemical Name: ((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl 2-hydroxyacetate
InChi Key: ZBBZROWQLKCFQK-KOLCDFICSA-N
InChi Code: InChI=1S/C16H20N6O3/c17-16-20-14(19-10-2-3-10)13-15(21-16)22(8-18-13)11-4-1-9(5-11)7-25-12(24)6-23/h1,4,8-11,23H,2-3,5-7H2,(H3,17,19,20,21)/t9-,11+/m1/s1
SMILES Code: O=C(OC[C@@H]1C=C[C@H](N2C=NC3=C(NC4CC4)N=C(N)N=C23)C1)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | KM-133 is potential treatment for plaque psoriasis. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.0 | 0.00 |
The following data is based on the product molecular weight 344.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
